Environmental Epigenetics: Crossroad between Public Health, Lifestyle, and Cancer Prevention

BioMed Research International
Massimo RomaniBarbara Banelli

Abstract

Epigenetics provides the key to transform the genetic information into phenotype and because of its reversibility it is considered an ideal target for therapeutic interventions. This paper reviews the basic mechanisms of epigenetic control: DNA methylation, histone modifications, chromatin remodeling, and ncRNA expression and their role in disease development. We describe also the influence of the environment, lifestyle, nutritional habits, and the psychological influence on epigenetic marks and how these factors are related to cancer and other diseases development. Finally we discuss the potential use of natural epigenetic modifiers in the chemoprevention of cancer to link together public health, environment, and lifestyle.

References

Jul 1, 1977·Journal of General Microbiology·R Y Stanier
Jan 1, 1983·Advances in Cancer Research·A D Riggs, P A Jones
Nov 1, 1994·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·M CravoC N Leitao
Sep 30, 2000·The American Journal of Clinical Nutrition·G C RampersaudL B Bailey
Apr 17, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·U LehmannH Kreipe
Aug 11, 2001·Science·T Jenuwein, C D Allis
Feb 23, 2002·Cell Death and Differentiation·I CascianoM Romani
Feb 23, 2002·Cell Death and Differentiation·I CascianoM Romani
Mar 7, 2002·The Journal of Nutrition·Matthew J RowlingKevin L Schalinske
Aug 7, 2002·The Journal of Nutrition·J Kevin DayDennis B Lubahn
Apr 19, 2003·Science·Amir EdenRudolf Jaenisch
Jul 11, 2003·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P BoyleH zur Hausen
Jul 26, 2003·Cancer Letters·M RomaniI Casciano
Sep 19, 2003·Nutrition Reviews·Gary L Johanning, Chandrika J Piyathilake
May 1, 1964·Proceedings of the National Academy of Sciences of the United States of America·V G ALLFREYA E MIRSKY
Nov 25, 2003·The New England Journal of Medicine·James G Herman, Stephen B Baylin
Jun 24, 2004·Nature Reviews. Genetics·Lin He, Gregory J Hannon
Aug 31, 2004·American Journal of Respiratory Cell and Molecular Biology·John A MarwickIrfan Rahman
Dec 8, 2004·Cancer Detection and Prevention·Helmut Bartsch, Jagadeesan Nair
Feb 26, 2005·Science·Takashi SakataniAndrew P Feinberg
May 11, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jean-Pierre J IssaHagop M Kantarjian
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Edvardas KaminskasUNKNOWN FDA
Jun 4, 2005·Science·Matthew D AnwayMichael K Skinner
Jul 23, 2005·Molecular Pharmacology·Won Jun LeeBao Ting Zhu
Oct 6, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ming Zhu FangChung S Yang
Feb 24, 2006·British Journal of Cancer·R M GlasspoolR Brown
May 13, 2006·Endocrinology·Matthew D Anway, Michael K Skinner
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Dec 22, 2006·The Journal of Nutrition·Mingzhu FangChung S Yang
Feb 16, 2007·The New England Journal of Medicine·Roger G Gosden, Andrew P Feinberg
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jean-Pierre J Issa

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Citations

Jan 7, 2016·Annual Review of Public Health·Gina M SolomonJohn B Faust
Dec 9, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Marcia A ChanCharles S Barnes
Jun 20, 2017·Nature Reviews. Nephrology·Paul G ShielsPeter Stenvinkel
Feb 21, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Michelle ThundersPeter Stockwell
Mar 21, 2018·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Chun-Xiao LuDong-Xu He
Nov 23, 2017·Archives of Disease in Childhood. Fetal and Neonatal Edition·Eloise Müller-SchulteAnja Harder
Apr 3, 2019·Journal of Cellular Biochemistry·Parisa PaydarHossein Fallah
Jul 2, 2017·Clinical Science·Anna WitaspLouise Nordfors
Jun 4, 2016·Oncotarget·Raquel C MontenegroSusanne Müller
May 7, 2020·Journal of Clinical Medicine·Anna ZubrzyckaMaria Zubrzycka
Mar 5, 2016·Molecular Medicine Reports·Ourania KoukouraDemetrios A Spandidos
Jun 15, 2017·Médecine sciences : M/S·Andrea MessinaVincent Prevot
Jun 20, 2019·Frontiers in Immunology·Giselle M BoukhaledConnie M Krawczyk
Mar 12, 2020·International Journal of Molecular Sciences·Giovanna C CavalcanteAmanda F Vidal
Jan 6, 2018·Journal of Cancer Prevention·Pritish Nilendu, Nilesh Kumar Sharma
Oct 30, 2016·The International Journal of Biological Markers·Xin JinTianli Niu
Mar 20, 2019·Current Nutrition Reports·Andrea Fuso, Marco Lucarelli
Dec 10, 2020·Cancers·Subhasree KumarJean-Pierre Etchegaray

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Methods Mentioned

BETA
electron microscopy
acetylation

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