Abstract
Asthma pathogenesis is a complex interaction of genetic, ethnic, environmental and social/life style risk factors. The goal of this study was to identify associations, if any, in children with asthma, between environmental risk factors (exposure to second-hand tobacco smoke (STS), pet ownership, race and a family history of asthma. After IRB approval, from June 2011 to December 2014, 823 children with asthma were enrolled in this prospective cross sectional study. At the initial visit, families completed a questionnaire with information on family history of asthma, having a pet at home and exposure to STS by parents at home. Chi square analyses were calculated, with alpha level of significance ≤0.05. History of asthma in parents, siblings or grandparents was reported by 575 (69.8%) patients including father (n = 154, 17.8%) and mother (n = 235, 26.5%). Children with family history of asthma (n = 575) were significantly more likely to have a pet at home and exposure to STS (n = 347, 60.3% and n = 198, 34.4%, respectively) compared to families without a history of asthma (n = 124, 50%, p = 0.006 and n = 44, 17.7%, p < 0.001, respectively). Similarly, asthmatic children with exposure to STS (n = 241) were significantly more likely...Continue Reading
References
Jul 1, 1996·American Journal of Respiratory and Critical Care Medicine·C J HolbergF D Martinez
Dec 24, 1997·Thorax·D P Strachan, D G Cook
Jul 11, 1998·Thorax·D P Strachan, D G Cook
Jul 21, 1998·JAMA : the Journal of the American Medical Association·E J Pérez-StableN L Benowitz
Apr 4, 2001·Allergy·C M Patiño, F D Martinez
Apr 20, 2002·Current Opinion in Allergy and Clinical Immunology·A Heinzmann, K A Deichmann
Jul 12, 2002·Nature·Paul Van EerdeweghTim P Keith
Feb 6, 2003·American Journal of Preventive Medicine·Wylie BurkeChris Carlsten
Sep 6, 2003·American Journal of Respiratory and Critical Care Medicine·Denise L LindEsteban González Burchard
Jan 15, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M WernerM Wjst
Feb 10, 2004·The Journal of Allergy and Clinical Immunology·James E GernRobert F Lemanske
Mar 4, 2005·Environmental Health Perspectives·Stephen E WilsonBruce P Lanphear
Mar 12, 2005·Annual Review of Public Health·Diane R Gold, Rosalind Wright
May 7, 2005·Allergy·S LauUNKNOWN Multicentre Allergy Study Group
Aug 9, 2005·The Journal of Allergy and Clinical Immunology·Carole Ober
Jan 6, 2006·Genes and Immunity·C Ober, S Hoffjan
Jan 7, 2006·Pediatrics·Marielena LaraHal Morgenstern
Jan 27, 2006·The New England Journal of Medicine·Christopher A HaimanLoïc Le Marchand
Oct 13, 2006·The Journal of Allergy and Clinical Immunology·L Keoki WilliamsChristine C Johnson
Dec 13, 2006·The Journal of Allergy and Clinical Immunology·Paloma CampoDavid I Bernstein
Jan 5, 2007·Proceedings of the American Thoracic Society·Kathleen C BarnesGeorgia M Dunston
Jul 4, 2007·Proceedings of the American Thoracic Society·Fernando D Martinez
Aug 19, 2007·American Journal of Respiratory and Critical Care Medicine·Craig P HershJuan C Celedón
Oct 19, 2007·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Mariam NaqviEsteban González Burchard
Apr 4, 2008·Pharmacogenomics·Katherine A DrakeEsteban González Burchard
Aug 16, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·J D BuffordJ E Gern
Jan 8, 2010·International Journal of Hygiene and Environmental Health·Chih-Mei ChenJoachim Heinrich
Sep 7, 2012·PloS One·Karin C Lødrup CarlsenUNKNOWN GALEN WP 1.5 ‘Birth Cohorts’ working group
May 16, 2013·Advances in Nutrition·Shelley McGuire
Citations
Nov 12, 2016·International Journal of Environmental Research and Public Health·Alesia Ferguson, Helena Solo-Gabriele
Mar 10, 2017·International Journal of Environmental Research and Public Health·Alesia FergusonHelena Solo-Gabriele
Dec 29, 2017·Annals of Human Genetics·Xulong CaiNa Lin
Apr 6, 2019·Molecular Genetics & Genomic Medicine·Xulong CaiGuanchi Ji
Dec 13, 2019·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Vincent OjwangSuvi M Virtanen
Sep 25, 2019·European Journal of Public Health·Maya Leventer-RobertsRan Balicer
Sep 12, 2020·Bioscience Reports·Giselmo Pinheiro LopesAngela Falcai
Jul 3, 2019·Medicine·Weijian ZhangHanmin Liu
Aug 22, 2018·Current Allergy and Asthma Reports·Paivi M SaloDarryl C Zeldin
Dec 7, 2018·International Archives of Allergy and Immunology·Rui JiangTianpen Cui
Nov 16, 2021·Frontiers in Pediatrics·Hongyao YuGuang-Hui Dong