Environmental exposures and their genetic or environmental contribution to depression and fatigue: a twin study in Sri Lanka.

BMC Psychiatry
Harriet A BallMatthew Hotopf

Abstract

There is very little genetically informative research identifying true environmental risks for psychiatric conditions. These may be best explored in regions with diverse environmental exposures. The current study aimed to explore similarities and differences in such risks contributing to depression and fatigue. Home interviews assessed depression (lifetime-ever), fatigue and environmental exposures in 4,024 randomly selected twins from a population-based register in the Colombo district of Sri Lanka. Early school leaving and standard of living showed environmentally-mediated effects on depression, in men. In women, life events were associated with depression partly through genetic pathways (however, the temporal order is consistent with life events being an outcome of depression, as well as the other way around). For fatigue, there were environmentally mediated effects (through early school leaving and life events) and strong suggestions of family-environmental influences. Compared to previous studies from higher-income countries, novel environmentally-mediated risk factors for depression and fatigue were identified in Sri Lanka. But as seen elsewhere, the association between life events and depression was partially genetically...Continue Reading

References

Jan 1, 1990·Acta geneticae medicae et gemellologiae·S OokiK Hayakawa
Mar 1, 1995·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·T ChalderS Wessely
Jan 1, 1994·Acta Psychiatrica Scandinavica. Supplementum·V Lehtinen, M Joukamaa
Aug 1, 1993·The American Journal of Psychiatry·K S KendlerL J Eaves
Jan 1, 1993·Journal of Psychosomatic Research·T ChalderE P Wallace
Jan 1, 1995·Epidemiologic Reviews·S Wessely
Dec 9, 1998·Journal of Child Psychology and Psychiatry, and Allied Disciplines·A ThaparP McGuffin
Mar 17, 1999·Archives of General Psychiatry·J SilbergL Eaves
Apr 28, 1999·Psychological Medicine·I HickieN Martin
Apr 28, 1999·Psychological Medicine·A FarmerP McGuffin
Oct 9, 1999·Social Science & Medicine·V PatelC Todd
Feb 7, 2001·The British Journal of Psychiatry : the Journal of Mental Science·A FarmerP McGuffin
Sep 29, 2000·The American Journal of Psychiatry·P F SullivanK S Kendler
Oct 12, 2000·Journal of Epidemiology and Community Health·T WattP Bech
May 2, 2001·The British Journal of Psychiatry : the Journal of Mental Science·V Patel, A Sumathipala
Jul 21, 2001·Twin Research : the Official Journal of the International Society for Twin Studies·A SumathipalaD J Fernando
Aug 3, 2001·The British Journal of Psychiatry : the Journal of Mental Science·J SilbergL Eaves
Nov 24, 2001·Psychosomatic Medicine·D BuchwaldJ Goldberg
May 2, 2002·The Australian and New Zealand Journal of Psychiatry·Christopher Tennant
May 3, 2003·Journal of Psychosomatic Research·Linda Fisher, Trudie Chalder
Jan 1, 1963·Acta Psychiatrica Scandinavica·E Slater
Feb 3, 2005·Social Psychiatry and Psychiatric Epidemiology·Richard J WilliamsonPak C Sham
Feb 9, 2005·Occupational Medicine·G Ranjith
May 5, 2005·BMJ : British Medical Journal·Vikram PatelDavid Mabey
Jun 23, 2005·Behavior Genetics·Shaun Purcell, Karestan C Koenen
Sep 20, 2005·Psychological Medicine·Patrick F SullivanNancy L Pedersen
Dec 22, 2005·The British Journal of Clinical Psychology·A BifulcoC Jacobs
Feb 24, 2006·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Michael RutterAvshalom Caspi
May 25, 2006·European Journal of Human Genetics : EJHG·Ian J DearyTimothy C Bates
Nov 8, 2006·Archives of General Psychiatry·Kenji KatoNancy L Pedersen
Jan 24, 2008·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jennifer Y F Lau, Thalia C Eley
Dec 2, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Harriet A BallMatthew Hotopf
Aug 4, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Harriet A BallMatthew Hotopf

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Citations

Jan 11, 2013·Twin Research and Human Genetics : the Official Journal of the International Society for Twin Studies·Athula SumathipalaDinesha Gunewardane
Sep 5, 2019·Social Psychiatry and Psychiatric Epidemiology·Helena M S ZavosFrühling V Rijsdijk

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