Abstract
In Japan, the prevalence of low birth weight (< 2,500 g) has been increasing, probably owing to leanness, exposure to toxic chemicals and smoking. Epidemiological studies revealed that low birth weight poses risks of hypertension, coronary heart diseases and diabetes. Although the precise mechanism has not been understood, there is an urgent need for appropriate public health interventions. MicroRNA (miRNA) is a small RNA consisting of approximately 22 nucleotides and distributed in a wide variety of organs and body fluids. miRNAs are involved in the pathogenesis of various human diseases and expected to be their potential biomarkers. The interest on the study on miRNA in the research field of developmental origins of health and disease (DOHaD) has been growing, and the number of related papers has been increasing. There are several molecular epidemiological studies on the relationship between maternal miRNA and fetal development. The effects of smoking and dietary factors on miRNA expression and fetal development have been investigated in epidemiological and experimental studies. However, the role of maternal miRNA in fetal development has not been well understood so far. In this review, the current status of studies on miRNA ...Continue Reading
References
May 10, 1986·Lancet·D J Barker, C Osmond
Feb 17, 2006·Molecular Human Reproduction·S SasakiR Kishi
Mar 10, 2007·American Journal of Obstetrics and Gynecology·Beth L PinelesChong Jai Kim
Apr 21, 2007·Journal of Internal Medicine·D J P Barker
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Mar 17, 2009·American Journal of Obstetrics and Gynecology·Xiao-ming ZhuYuan-qing Yao
Apr 24, 2009·Developmental Cell·Alessandro RosaAli H Brivanlou
Jul 22, 2010·Epigenetics : Official Journal of the DNA Methylation Society·Matthew A MaccaniCarmen J Marsit
Sep 28, 2010·Nucleic Acids Research·Shi-Lung LinDavid T S Wu
Jun 4, 2011·Amino Acids·X D LiuG Y Wu
Aug 2, 2011·The American Journal of Pathology·Deug-Chan LeeChong Jai Kim
Mar 1, 2012·PloS One·Yu YamauraTsuyoshi Yokoi
Mar 3, 2012·Differentiation; Research in Biological Diversity·Walter LiszewskiHarold S Bernstein
Mar 24, 2012·Epigenetics : Official Journal of the DNA Methylation Society·Emma L MarczyloTimothy H Marczylo
Mar 29, 2013·The New England Journal of Medicine·Harry L A JanssenMichael R Hodges
Apr 1, 2014·American Journal of Perinatology·Dan WangGui-Yu Song
May 3, 2014·Journal of Perinatology : Official Journal of the California Perinatal Association·H JiangG Xu
Jul 13, 2014·Placenta·K MiuraH Masuzaki
Oct 3, 2014·Prenatal Diagnosis·Kiyonori MiuraHideaki Masuzaki
Nov 2, 2014·Asian-Australasian Journal of Animal Sciences·Shiyan SuiRuqian Zhao
Apr 3, 2015·International Journal of Obesity : Journal of the International Association for the Study of Obesity·S MuralimanoharanA Maloyan