Environmental genomics: a key to understanding biology, pathophysiology and disease

Human Molecular Genetics
David A SchwartzElwood A Linney

Abstract

Recent advances in human and molecular genetics provide an unparalleled opportunity to understand how genes and genetic changes interact with environmental stimuli to either preserve health or cause disease. The fields of environmental genetics and environmental genomics has enormous potential to affect our ability to accurately assess the risk of developing disease, identify and understand basic pathogenic mechanisms that are critical to disease progression, and to more precisely phenotype disease subtypes. However, the application of genetics and genomics to problems in environmental health is only the beginning yet, by itself, represents a potentially effective strategy to substantially impact morbidity and mortality. Collaborative approaches that team together environmental scientists with molecular biologists, geneticists, physiologists and physician scientists are critical to the investigation of environmental aspects of human health. Moreover, exploiting eukaryotic model systems (yeast, Caenorhabditis elegans, zebrafish, Drosophila and rodents) will accelerate our understanding of environmental exposures on human health.

Citations

May 6, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Carolyn J MattinglyJames L Boyer
May 11, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·June K DunnickGregory S Travlos
Jul 9, 2005·Environmental Health Perspectives·Brenda K WeisSamuel H Wilson
Jun 20, 2007·Trends in Biotechnology·Miguel Cacho TeixeiraIsabel Sá-Correia
Sep 12, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·David J DixRobert J Kavlock
Jun 4, 2014·Palliative & Supportive Care·Joy Penman, Bronwyn Ellis
Jul 19, 2016·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Mingon KangJean Gao
Aug 12, 2006·Journal of Experimental Zoology. Part A, Comparative Experimental Biology·Chris T Amemiya, Marta Gomez-Chiarri
Jul 29, 2010·Journal of the History of Biology·Miguel García-Sancho
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