Environmental influences on endovascular stent platelet reactivity: an in vitro comparison of stainless steel and gold surfaces

Journal of Biomedical Materials Research. Part a
Kumaran Kolandaivelu, E R Edelman

Abstract

Thrombosis is an initiating reaction to vascular injury that follows the placement of vascular devices. Platelets play a crucial role in this response. Their interaction with endovascular devices is not solely a function of device properties, but a multifaceted response dependent on several biological factors that interact in the context of a hemodynamic environment. We sought to investigate the role of local environmental variations on determining indices of biocompatibility. Using a recently described in vitro flow apparatus, we separately studied the platelet and coagulative component responses to stainless steel endovascular stents with and without gold coating. When allowed to interact, these biological mediators of thrombosis enabled varied biocompatibility outcomes in a manner that was dependent on flow. Using platelet reactivity as an index, the stainless steel faired better under some conditions, while under other conditions, gold was superior. Considering such impacts of local environment on biocompatibility is important, both in the interpretation of experimental findings, as well as the continued use and optimized development of vascular devices.

References

May 1, 1992·Journal of Biomedical Materials Research·G Rollason, M V Sefton
Jan 1, 1990·Annals of Biomedical Engineering·D Basmadjian
Aug 1, 1994·Biomaterials·J M CourtneyC D Forbes
Mar 1, 1994·Annals of Biomedical Engineering·K Gregory, D Basmadjian
Mar 4, 1997·Circulation·D S Baim, J P Carrozza
Oct 23, 1997·Journal of Biomedical Materials Research·C Eriksson, H Nygren
May 1, 1995·Academic Radiology·N TanigawaM Kobayashi
May 29, 1999·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·S De ServiC Klersy
Jan 4, 2001·The American Journal of Cardiology·A KastratiA Schömig
Feb 7, 2001·Circulation·E R EdelmanC Rogers
Feb 25, 2003·Journal of Biomechanical Engineering·Kumaran Kolandaivelu, Elazer R Edelman

❮ Previous
Next ❯

Citations

Nov 12, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Chandan PulletikurthiSharan Ramaswamy
Aug 1, 2013·Circulation. Cardiovascular Interventions·Michael J EppihimerJuan F Granada
Oct 31, 2006·Journal of Biomedical Materials Research. Part a·Chun-Che ShihYea-Yang Su
May 3, 2012·Annals of the New York Academy of Sciences·Jordi MartorellMercedes Balcells
Feb 24, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Da-Guang YuMing-Chien Yang
Apr 16, 2021·Platelets·M Urooj ZafarJuan Jose Badimon

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.