Abstract
Thrombosis is an initiating reaction to vascular injury that follows the placement of vascular devices. Platelets play a crucial role in this response. Their interaction with endovascular devices is not solely a function of device properties, but a multifaceted response dependent on several biological factors that interact in the context of a hemodynamic environment. We sought to investigate the role of local environmental variations on determining indices of biocompatibility. Using a recently described in vitro flow apparatus, we separately studied the platelet and coagulative component responses to stainless steel endovascular stents with and without gold coating. When allowed to interact, these biological mediators of thrombosis enabled varied biocompatibility outcomes in a manner that was dependent on flow. Using platelet reactivity as an index, the stainless steel faired better under some conditions, while under other conditions, gold was superior. Considering such impacts of local environment on biocompatibility is important, both in the interpretation of experimental findings, as well as the continued use and optimized development of vascular devices.
References
May 1, 1992·Journal of Biomedical Materials Research·G Rollason, M V Sefton
Jan 1, 1990·Annals of Biomedical Engineering·D Basmadjian
Aug 1, 1988·Acta Physiologica Scandinavica·H NygrenM Stenberg
Jun 15, 1995·Circulation·C Rogers, E R Edelman
Aug 1, 1994·Biomaterials·J M CourtneyC D Forbes
Mar 1, 1994·Annals of Biomedical Engineering·K Gregory, D Basmadjian
Jan 26, 1996·Cell·B SavageZ M Ruggeri
Apr 25, 1996·The New England Journal of Medicine·A SchömigK Ulm
Mar 15, 1996·Circulation·N Maalej, J D Folts
Dec 1, 1996·Biomaterials·S KanagarajaP Tengvall
Mar 4, 1997·Circulation·D S Baim, J P Carrozza
Apr 1, 1997·Thrombosis Research·K GutensohnP Kuehnl
Oct 23, 1997·Journal of Biomedical Materials Research·C Eriksson, H Nygren
Dec 31, 1997·Circulation·D J SchneiderB E Sobel
May 1, 1995·Academic Radiology·N TanigawaM Kobayashi
Jan 16, 1998·Biomaterials·D BasmadjianS A Baldwin
Sep 19, 1998·Cell·B SavageZ M Ruggeri
May 7, 1999·Thrombosis Research·C BeythienW Terres
May 29, 1999·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·S De ServiC Klersy
Jun 1, 2000·Circulation·A KastratiF J Neumann
Sep 23, 2000·Nature·S R Coughlin
Jan 4, 2001·The American Journal of Cardiology·A KastratiA Schömig
Feb 7, 2001·Circulation·E R EdelmanC Rogers
Apr 18, 2001·Circulation·D E CutlipR E Kuntz
Feb 25, 2003·Journal of Biomechanical Engineering·Kumaran Kolandaivelu, Elazer R Edelman
Citations
Mar 23, 2011·Circulation·Kumaran KolandaiveluElazer R Edelman
Nov 12, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Chandan PulletikurthiSharan Ramaswamy
Aug 1, 2013·Circulation. Cardiovascular Interventions·Michael J EppihimerJuan F Granada
Oct 31, 2006·Journal of Biomedical Materials Research. Part a·Chun-Che ShihYea-Yang Su
Feb 10, 2009·European Journal of Clinical Investigation·J J J SmitA W J van 't Hof
Mar 29, 2012·Acta Biologica Hungarica·G KaszaEva Gömöri
May 3, 2012·Annals of the New York Academy of Sciences·Jordi MartorellMercedes Balcells
Feb 24, 2007·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Da-Guang YuMing-Chien Yang
Sep 1, 2015·JACC. Cardiovascular Interventions·Antonios P AntoniadisYiannis S Chatzizisis
Apr 16, 2021·Platelets·M Urooj ZafarJuan Jose Badimon