PMID: 7398743Jul 1, 1980Paper

Environmental influences on human foetal and placental xenobiotic metabolism

European Journal of Clinical Pharmacology
O Pelkonen

Abstract

The human foetus is more capable of metabolizing xenobiotics than foetuses of common laboratory animal species. However, xenobiotic metabolism in animal foetuses is inducible by the exposure of the mother to various inducers during late pregnancy. Xenobiotic metabolism in neonates is more easily inducible than in foetal animals. With respect to the human foetus at mid-pregnancy, the hepatic enzyme systems do not seem to be readily inducible by exoaenous inducers, whereas the placental monooxygenase system is almost totaly dependent on maternal cigarette smoking. In the human newborn, indirect evidence points to the possibility of induction by potential inducers. The ontogenetic development of xenobiotic metabolism is probably regulated by endogenous hormones. It is possible that environmental factors may effect these normal regulatory and "imprinting" phenomena and thus lead to permanent disturbances in xenobiotic metabolism.

References

Oct 1, 1976·The Journal of Pharmacy and Pharmacology·B Testa, B Jenner
Jan 1, 1979·European Journal of Drug Metabolism and Pharmacokinetics·J Pütter
Jan 1, 1977·Advances in Cancer Research·S S Thorgeirsson, D W Nebert
Jan 1, 1978·Annual Review of Pharmacology and Toxicology·G J Dutton
Sep 1, 1979·Biochemical Pharmacology·N P Illsley, C A Lamartiniere
Mar 1, 1978·Clinical Pharmacology and Therapeutics·W PitlickC Pippenger
Jun 1, 1976·Toxicology and Applied Pharmacology·D L BerryM R Juchau
Dec 1, 1975·Canadian Journal of Physiology and Pharmacology·J U BellD J Ecobichon
Apr 4, 1975·European Journal of Clinical Pharmacology·A RaneL Palmér
Jan 1, 1976·Toxicology and Applied Pharmacology·J U BellD J Ecobichon
Jan 1, 1974·Naunyn-Schmiedeberg's Archives of Pharmacology·E Schlede, H J Merker
Dec 1, 1973·European Journal of Clinical Pharmacology·B JallingS Agurell
Nov 10, 1972·Science·A H Conney, J J Burns
Jan 1, 1971·Acta Pharmacologica Et Toxicologica·O PelkonenN T Kärki
Jan 1, 1980·Pharmacology & Therapeutics·M R Juchau
Jan 1, 1980·Pharmacology & Therapeutics·O Pelkonen
Mar 12, 1965·Annals of the New York Academy of Sciences·J R FOUTS, L G HART

Citations

Jan 1, 1983·American Journal of Industrial Medicine·R K Miller
Jan 1, 1983·European Journal of Clinical Pharmacology·M T SmithE J Triggs
Mar 1, 1986·Journal of Steroid Biochemistry·M Pasanen, O Pelkonen
Jan 1, 1982·Pharmacology & Therapeutics·B M Assael
Nov 1, 1988·Clinical and Experimental Pharmacology & Physiology·R M KluckR G Dickinson
Jun 1, 1984·Chemico-biological Interactions·H AutrupC C Hsia
Dec 1, 1987·Regulatory Toxicology and Pharmacology : RTP·W Slikker
Jan 6, 2000·Regulatory Toxicology and Pharmacology : RTP·G J Burin, D R Saunders
Dec 3, 1981·The New England Journal of Medicine·E Farber
Jun 15, 1982·Biochemical and Biophysical Research Communications·T CresteilJ P Leroux
Jan 1, 1989·Journal of Biochemical Toxicology·M H Bilimoria, D J Ecobichon
Oct 1, 1983·Journal of Applied Toxicology : JAT·S TabacovaL Balabaeva

Related Concepts

Pharmaceutical Preparations
Impacts, Environmental
Enzyme Induction
Fetal Structures
Hormones
Maternal-Fetal Exchange
Microsomes
Placenta
Cigar smoker

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.