Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration.

Molecular Pharmacology
Chunjuan SongArthi Kanthasamy

Abstract

Pesticide exposure has been implicated in the etiopathogenesis of Parkinson's disease (PD); in particular, the organochlorine insecticide dieldrin is believed to be associated with PD. Emerging evidence indicates that histone modifications play a critical role in cell death. In this study, we examined the effects of dieldrin treatment on histone acetylation and its role in dieldrin-induced apoptotic cell death in dopaminergic neuronal cells. In mesencephalic dopaminergic neuronal cells, dieldrin induced a time-dependent increase in the acetylation of core histones H3 and H4. Histone acetylation occurred within 10 min of dieldrin exposure indicating that acetylation is an early event in dieldrin neurotoxicity. The hyperacetylation was attributed to dieldrin-induced proteasomal dysfunction, resulting in accumulation of a key histone acetyltransferase (HAT), cAMP response element-binding protein. The novel HAT inhibitor anacardic acid significantly attenuated dieldrin-induced histone acetylation, Protein kinase C delta proteolytic activation and DNA fragmentation in dopaminergic cells protected against dopaminergic neuronal degeneration in primary mesencephalic neuronal cultures. Furthermore, 30-day exposure of dieldrin in mouse m...Continue Reading

References

Jul 1, 1994·Annals of Neurology·L FlemingJ R Sanchez-Ramos
Mar 1, 1996·Human & Experimental Toxicology·F M CorriganL Murray
Oct 31, 1998·Brain Research. Molecular Brain Research·A SalminenT Suuronen
Feb 15, 2000·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·L ZhongJ A Hanley
Mar 8, 2000·Journal of Toxicology and Environmental Health. Part a·F M CorriganD Mann
Mar 15, 2001·Current Opinion in Cell Biology·H ChenR M Evans
Jan 5, 2002·Early Human Development·C CampoyJ A Molina-Font
Jun 29, 2002·Reviews on Environmental Health·David G Le CouteurAllan J McLean
Aug 20, 2002·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Sameez Hasan, Michael O Hottiger
Feb 4, 2003·Journal of Neurochemistry·Anne-Laurence BoutillierJean-Philippe Loeffler
Mar 8, 2003·The Journal of Biological Chemistry·Karanam BalasubramanyamTapas K Kundu
Dec 6, 2003·The EMBO Journal·Caroline RouauxAnne-Laurence Boutillier
Jul 13, 2004·Cancer Treatment Reviews·Raz SomechAmos J Simon
Aug 13, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M T S TrevisanR W Owen
Aug 23, 2005·Neurotoxicology·Anumantha G KanthasamyVellareddy Anantharam
Sep 17, 2005·Cell Death and Differentiation·R N Saha, K Pahan
Feb 13, 2007·Experimental Neurology·Jaime M HatcherGary W Miller
Apr 13, 2007·Expert Review of Anticancer Therapy·Douglas Marchion, Pamela Münster
May 18, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Danhui ZhangAnumantha Kanthasamy
May 29, 2007·Experimental Gerontology·Nicolle BaderTilman Grune
Sep 19, 2007·Molecular Cancer Therapeutics·Elena D EliseevaMira O Jung
Dec 7, 2007·British Journal of Pharmacology·F CondorelliP L Canonico
Oct 28, 2008·Mutation Research·Lucia Migliore, Fabio Coppedè
Jan 10, 2009·Science·Bo Chen, Constance L Cepko
May 12, 2009·Epigenetics : Official Journal of the DNA Methylation Society·Francesc X SorianoGiles E Hardingham

❮ Previous
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Citations

Sep 1, 2011·Journal of Ocular Biology, Diseases, and Informatics·Pamela S Lagali, David J Picketts
Sep 6, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Anne SchneiderAnne-Laurence Boutillier
Sep 14, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Navneet Ammal KaideryBobby Thomas
Oct 1, 2013·Environmental Toxicology and Pharmacology·Jaromir MichałowiczBożena Bukowska
Jul 16, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael J Frank, John A Fossella
Sep 15, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jason R Cannon, J Timothy Greenamyre
May 25, 2012·TheScientificWorldJournal·Fabio Coppedè
Nov 30, 2011·Epigenomics·John B J Kwok
Oct 27, 2010·International Journal of Cell Biology·Go-Woon KimXiang-Jiao Yang
Oct 20, 2012·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ken-Ichi Watanabe, Wilhelm Bloch
Apr 13, 2011·Expert Opinion on Drug Metabolism & Toxicology·Thomas Müller
Dec 4, 2013·The Nursing Clinics of North America·Ashley Erin ClarkJacquelyn Y Taylor
Feb 6, 2013·Toxicology·M CollottaV Bollati
Jan 29, 2013·Toxicology·Elena VakonakiDemetrios A Spandidos
Feb 14, 2013·Toxicology and Applied Pharmacology·Sara Mostafalou, Mohammad Abdollahi
Feb 22, 2012·Neurotoxicology·Anumantha KanthasamyArthi Kanthasamy
Nov 8, 2011·Experimental Gerontology·Manuel CarloniRosita Gabbianelli
Aug 23, 2011·Toxicology and Applied Pharmacology·Hilary Afeseh NgwaAnumantha G Kanthasamy
Sep 14, 2010·Biochimica Et Biophysica Acta·B Ruthrotha SelviAnne-Laurence Boutillier
Dec 24, 2015·Stem Cells International·Rubén Fernández-Santiago, Mario Ezquerra
Feb 24, 2015·Journal of Neuroscience Research·Shen LinGeorge M Smith
Jan 19, 2012·International Journal of Epidemiology·Lifang HouAndrea Baccarelli
Jan 3, 2015·Journal of the Neurological Sciences·Ya FengYun-Cheng Wu
Jun 15, 2015·Progress in Neurobiology·Roy LardenoijeBart P F Rutten
Jul 15, 2015·Molecular Neurobiology·Charlene Siew-Hon TanWei-Yi Ong
Jul 12, 2012·Molecular Aspects of Medicine·Irfan A Qureshi, Mark F Mehler
Jul 30, 2014·Frontiers in Genetics·Fabio Coppedè
Jun 16, 2016·Lancet Neurology·Bryan Maloney, Debomoy K Lahiri
Jul 1, 2016·Acta Neuropathologica·Catherine LabbéOwen A Ross
Oct 30, 2016·Journal of Parkinson's Disease·Jennifer L Jakubowski, Viviane Labrie
Oct 19, 2017·Archives of Pharmacal Research·Qudeer Ahmed AbdulJae Sue Choi

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