Abstract
Hypertrophic pyloric stenosis (HPS) is a condition noted within the first several weeks of life that results in hypertrophy of the pyloric muscle between the stomach and duodenum. The etiology has not been elucidated but genetic and environmental influences are suspected. We hypothesized that agricultural pesticides would be associated with an increased incidence of pyloric stenosis. Data from infants with HPS were obtained from the Indiana Birth Defects Registry (IBDR) for all counties in Indiana from 2005 to 2009. Data from all live births were obtained from the Indiana State Health Department (ISHD). Maternal demographics and clinical characteristics of infants were abstracted. The US Geological Survey (USGS) provided estimated use of agricultural pesticides (EPEST), and these values were correlated with HPS incidence. Univariate and multivariate logistical regression models were used to assess the association between HPS risk and pesticide use. A total of 442,329 newborns were studied with 1313 HPS cases recorded. The incidence of HPS was 30/10,000 live births. HPS incidence was correlated with total county pesticide use, as well as subcategories of pesticides (fungicides, fumigants, insecticides, herbicides). Indiana count...Continue Reading
References
Jan 1, 1970·The Journal of Pediatrics·W K ShimS W Wright
May 1, 1993·Irish Journal of Medical Science·J M O'DonoghueJ R Flynn
May 11, 1999·Drug and Chemical Toxicology·M R RaoV Sekhar
Aug 12, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·Stephen J KeelyAlan F Hofmann
Jun 15, 2007·Journal of Pediatric Surgery·Kelly D MattixL R Tres Scherer
Feb 3, 2009·Acta Paediatrica·Paul D WinchesterJun Ying
Jun 17, 2010·JAMA : the Journal of the American Medical Association·Camilla KroghMads Melbye
May 12, 2011·PloS One·Mee-Mee LeongAn-Chyi Chen
Sep 15, 2011·Tropical Doctor·P W Saula, G P Hadley
Jan 17, 2012·Journal of Pediatric Surgery·Sabina SiddiquiAlfred P Kennedy
May 4, 2012·American Journal of Epidemiology·Camilla KroghThea K Fischer
Sep 15, 2012·Reproductive Toxicology·Mohan ManikkamMichael K Skinner
Oct 6, 2012·The Journal of Pediatrics·A Jack AgopianPhilip J Lupo
Jan 30, 2013·PloS One·Mohan ManikkamMichael K Skinner
Mar 5, 2013·Reproductive Toxicology·Rebecca TraceyMichael K Skinner
Mar 16, 2013·American Journal of Medical Genetics. Part a·A J AgopianPeter H Langlois
Apr 23, 2013·Ecotoxicology and Environmental Safety·Liang-Liang WangShi-Wen Xu
Jul 16, 2013·Social Science & Medicine·Judith E B van der WaerdenMaria W J Jansen
Jul 23, 2013·International Journal of Hygiene and Environmental Health·Christine KielbUNKNOWN National Birth Defects Prevention Study
Oct 8, 2013·Journal of Pediatric Surgery·Kevin A GrahamAlan P Ladd
Oct 30, 2013·Pediatrics·Suzan L CarmichaelGary M Shaw
Jan 21, 2014·Journal of Pediatric Surgery·Obinna O AdibeShawn D St Peter
Feb 12, 2014·PloS One·Arun ChaudhuryMaryrose P Sullivan
Mar 13, 2014·BMJ : British Medical Journal·Marie LundMads Melbye
Citations
Feb 9, 2016·The Science of the Total Environment·Michael HoubrakenPieter Spanoghe
Aug 16, 2016·Seminars in Pediatric Surgery·Matthew Jobson, Nigel J Hall
Jul 14, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jing LiXiang Liu
Dec 15, 2018·Birth Defects Research·Renuka KapoorPaul A Romitti
Aug 27, 2019·ANZ Journal of Surgery·Annie YauJonathan M Wells
Apr 17, 2020·Birth Defects Research·Chantal A Ten KateErwin Brosens
Apr 28, 2019·Environmental Monitoring and Assessment·Abukari WumbeiPieter Spanoghe
Jan 29, 2020·Journal of Pediatric Gastroenterology and Nutrition·Maya ParanZvi Steiner
Sep 8, 2017·International Journal of Environmental Health Research·Carmen I R Froes AsmusLuz Claudio
Nov 22, 2019·Hospital Pediatrics·Keyur DondaFredrick Dapaah-Siakwan
Aug 3, 2019·Toxics·Becky TalynErik Melchiorre
Nov 16, 2019·Biosensors·Md Abul KashemMasayasu Suzuki
Aug 12, 2020·The Science of the Total Environment·Md Panna AliNur Ahmed
Apr 23, 2021·Environmental Research·Laëtitia PerrinAlexis Ebaz
May 8, 2021·Scientific Reports·Yaodan ZhangChangyan Zhou