Environmental pesticides increase the risk of developing hypertrophic pyloric stenosis

Journal of Pediatric Surgery
Troy A MarkelPaul D Winchester

Abstract

Hypertrophic pyloric stenosis (HPS) is a condition noted within the first several weeks of life that results in hypertrophy of the pyloric muscle between the stomach and duodenum. The etiology has not been elucidated but genetic and environmental influences are suspected. We hypothesized that agricultural pesticides would be associated with an increased incidence of pyloric stenosis. Data from infants with HPS were obtained from the Indiana Birth Defects Registry (IBDR) for all counties in Indiana from 2005 to 2009. Data from all live births were obtained from the Indiana State Health Department (ISHD). Maternal demographics and clinical characteristics of infants were abstracted. The US Geological Survey (USGS) provided estimated use of agricultural pesticides (EPEST), and these values were correlated with HPS incidence. Univariate and multivariate logistical regression models were used to assess the association between HPS risk and pesticide use. A total of 442,329 newborns were studied with 1313 HPS cases recorded. The incidence of HPS was 30/10,000 live births. HPS incidence was correlated with total county pesticide use, as well as subcategories of pesticides (fungicides, fumigants, insecticides, herbicides). Indiana count...Continue Reading

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Citations

Aug 16, 2016·Seminars in Pediatric Surgery·Matthew Jobson, Nigel J Hall
Jul 14, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jing LiXiang Liu
Aug 27, 2019·ANZ Journal of Surgery·Annie YauJonathan M Wells
Apr 17, 2020·Birth Defects Research·Chantal A Ten KateErwin Brosens
Apr 28, 2019·Environmental Monitoring and Assessment·Abukari WumbeiPieter Spanoghe
Jan 29, 2020·Journal of Pediatric Gastroenterology and Nutrition·Maya ParanZvi Steiner
Sep 8, 2017·International Journal of Environmental Health Research·Carmen I R Froes AsmusLuz Claudio

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