Environmental pollutants in maternal milk and cryptorchidism

Gynécologie, obstétrique & fertilité
Françoise Brucker-DavisPatrick Fénichel

Abstract

Numerous maternal lipophilic compounds are eliminated into milk during lactation, their concentrations reflecting fetal in utero exposure. Some of them are endocrine disruptors. Their role in the occurrence of genital malformation, dysfunction or cancer has been suggested. We wanted to study the exposure of our population and its potential association with cryptorchidism, as few clinical studies are available. Over three years, we screened for cryptorchidism all boys born alive at or above 34 weeks of gestational age, in two maternity wards (CHU Nice, CHG Grasse). Cryptorchid boys were matched with two controls. Nursing mothers provided a colostrum sample that was screened for 15 compounds known for their antiandrogenic and/or anti estrogenic properties, including dichloro-diphenyl-trichloro-ethylene (DDE), polychlorinated biphenyls (PCBs), dibutylphthalate (DBP) (& metabolite monobutylphthalate-mBP) and hexachlorobenzene (HCB). Out of 6246 boys, 102 were cryptorchid (1.6%). All available colostrums (56 for cryptorchid and 69 for controls) were contaminated. Median concentrations of DDE, PCBs, HCB and phthalates were higher though not significantly in cryptorchid versus controls. Cryptorchid boys were more likely to be classifi...Continue Reading

References

Mar 1, 1993·Bulletin of Environmental Contamination and Toxicology·F BordetA Venant
Oct 1, 1996·Environmental Health Perspectives·J García-RodríguezP Lardelli-Claret
May 22, 1998·Bulletin of Environmental Contamination and Toxicology·J K KinyamuT E Maitho
Feb 24, 2001·European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [et Al] = Zeitschrift Für Kinderchirurgie·S HosieK L Waag
Jun 11, 2002·Environmental Health Perspectives·Gina M Solomon, Pilar M Weiss
Aug 31, 2002·Archives of Environmental Contamination and Toxicology·C K C WongM H Wong
Jan 1, 2003·Reproductive Toxicology·Timothy J Schrader, Gerard M Cooke
Feb 27, 2003·Annals of Epidemiology·Beth C GladenRuth E Little
Apr 30, 2003·Bulletin of Environmental Contamination and Toxicology·T Cajka, J Hajslová
Jul 5, 2003·Environmental Health Perspectives·Pierre AyotteUNKNOWN Inuit Cohort Study
Oct 7, 2003·Environmental Health Perspectives·Philip LandriganDaniel B J Droller
Apr 29, 2004·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Antonia M CalafatLarry L Needham
Sep 4, 2004·Environmental Health Perspectives·Jenny PronczukConstanza Vallenas
Feb 22, 2005·Environmental Research·Núria Ribas-FitóJordi Sunyer
Aug 5, 2005·Environmental Health Perspectives·Shanna H SwanUNKNOWN Study for Future Families Research Team
Sep 13, 2005·Chemosphere·How-Ran ChaoXu-Hui Chung
Feb 10, 2006·International Journal of Andrology·Thea M EdwardsLouis J Guillette
Mar 9, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·Katrine BayAnna-Maria Andersson
Jul 13, 2006·Environmental Health Perspectives·Ida N DamgaardUNKNOWN Nordic Cryptorchidism Study Group
Oct 20, 2006·The Journal of Steroid Biochemistry and Molecular Biology·J ToppariK M Main
May 27, 2008·Human Reproduction·Françoise Brucker-DavisUNKNOWN Cryptorchidism Study Group from Nice Area

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