Environmental Risk Factors and Psychotic-like Experiences in Children Aged 9-10.

Journal of the American Academy of Child and Adolescent Psychiatry
Nicole R KarcherDeanna M Barch

Abstract

Research implicates environmental risk factors, including correlates of urbanicity, deprivation, and environmental toxins, in psychotic-like experiences (PLEs). The current study examined associations between several types of environmental risk factors and PLEs in school-age children, whether these associations were specific to PLEs or generalized to other psychopathology, and examined possible neural mechanisms for significant associations. The current study used cross-sectional data from 10,328 children 9-10 years old from the Adolescent Brain Cognitive Development (ABCD) Study. Hierarchical linear models examined associations between PLEs and geocoded environmental risk factors and whether associations generalized to internalizing/externalizing symptoms. Mediation models examined evidence of structural magnetic resonance imaging abnormalities (eg, intracranial volume) potentially mediating associations between PLEs and environmental risk factors. Specific types of environmental risk factors, namely, measures of urbanicity (eg, drug offense exposure, less perception of neighborhood safety), deprivation (eg, overall deprivation, poverty rate), and lead exposure risk, were associated with PLEs. These associations showed evidenc...Continue Reading

References

Aug 1, 1995·Alcoholism, Clinical and Experimental Research·J P RiceH Begleiter
Sep 24, 1999·Nature Neuroscience·J N GieddJ L Rapoport
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·B Fischl, A M Dale
Jun 29, 2004·NeuroImage·F SégonneB Fischl
May 16, 2008·Biometrical Journal. Biometrische Zeitschrift·Torsten HothornPeter Westfall
Nov 12, 2010·Nature·Jim van OsBart P F Rutten
Mar 24, 2012·Environmental Health Perspectives·Frederica P PereraVirginia Rauh
Mar 31, 2012·Science·Chi-Hua ChenAnders M Dale
Jan 10, 2013·Neuroscience·C W HoltzmanE F Walker
May 21, 2013·Biological Psychiatry·Joshua FlatowBrian J Miller
Jun 7, 2014·Schizophrenia Bulletin·Diana PaksarianCarsten B Pedersen
Dec 2, 2014·Annals of Internal Medicine·Amy J H KindMaureen Smith
Mar 10, 2016·Pediatrics·Sara B JohnsonKimberly G Noble
Mar 30, 2016·Environmental Science & Technology·Qian DiJoel Schwartz
May 15, 2016·Social Psychiatry and Psychiatric Epidemiology·Brian O'DonoghueAbbie Lane
Jan 4, 2017·PloS One·Aleida FrissenUNKNOWN Genetic Risk and Outcome in Psychosis (G.R.O.U.P.)
Aug 29, 2017·The Annals of the American Academy of Political and Social Science·Christopher R BrowningDana Haynie
Nov 28, 2017·Psychiatry Research. Neuroimaging·Aleida FrissenUNKNOWN for Genetic Risk and Outcome in Psychosis (G.R.O.U.P.)
Jul 17, 2018·Current Environmental Health Reports·Paula de Prado BertMarion Mortamais
Aug 20, 2018·Schizophrenia Research·Martin K RimvallPia Jeppesen
Dec 14, 2018·Nature Communications·Chun Chieh FanCarsten Bøcker Pedersen
Feb 7, 2019·Current Opinion in Psychiatry·Anne-Kathrin J FettLydia Krabbendam
Mar 28, 2019·JAMA Psychiatry·Joanne B NewburyHelen L Fisher
Jan 15, 2020·Nature Medicine·Andrew T MarshallElizabeth R Sowell

❮ Previous
Next ❯

Citations

Jan 26, 2021·Schizophrenia Research·Laura S DaedelowUNKNOWN IMAGEN Consortium
Jun 18, 2021·Social Science & Medicine·Gergő BaranyiJamie Pearce
Jul 17, 2021·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Nicole R KarcherRyan Bogdan

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.