Environmental risk factors in congenital malformations of the eye

Annals of Tropical Paediatrics
S J HornbyR Barry Jones

Abstract

Developmental eye defects such as coloboma are a significant cause of visual morbidity in children, and are more common in India than elsewhere. The possible role of environmental factors in the aetiology of these conditions was investigated by studying birth order, symptoms of vitamin A deficiency (night blindness), drug use and maternal illness in pregnancy, rubella antibodies and exposure to agricultural chemicals. Through hospital records and community-based rehabilitation programmes in Andhra Pradesh, children with colobomata were recruited from schools for the blind. Eighty-three mothers of affected children were interviewed. The results showed that 43% of parents were consanguineous, that 19% had a positive family history and that the frequency of coloboma was highest in second-born children. Eleven (16%) mothers had a history of night blindness while pregnant with the affected child; seven (8%) took medication during the 1st trimester, abortifacients in two cases; three reported fever in the 1st trimester; and 11 (13%) reported exposure to agricultural chemicals.

References

Sep 1, 1979·American Journal of Ophthalmology·A NakajimaN Yasuda
Nov 1, 1976·American Journal of Ophthalmology·G O WaringM M Rodrigues
Sep 1, 1992·Ophthalmic Paediatrics and Genetics·C StollM P Roth
Sep 21, 1991·Lancet·J C PonsE Papiernik
Jul 1, 1991·Current Eye Research·E R HoogenboomF J Zeman
Nov 1, 1989·Archives of Ophthalmology·A H WeissJ Longbottom
Aug 1, 1987·Journal of Medical Genetics·R M Winter, M Baraitser
Jan 1, 1981·Survey of Ophthalmology·R A Pagon
Apr 16, 1994·BMJ : British Medical Journal·D W BrownE Miller
Jan 15, 1994·BMJ : British Medical Journal·F BianchiR Tenconi
Jan 15, 1994·BMJ : British Medical Journal·P Kristensen, L M Irgens
Aug 1, 1993·Journal of Medical Genetics·M Warburg
Jan 20, 1996·BMJ : British Medical Journal·M B EcksteinP Vijayalakshmi
Mar 7, 1998·American Journal of Medical Genetics·E Bermejo, M L Martínez-Frías
Aug 26, 1998·Ophthalmology·D R DaufenbachR V Keech
Oct 3, 1998·BMJ : British Medical Journal·H DolkP H Walls
Apr 20, 1999·International Review of Cytology·G M Morriss-Kay, S J Ward
Aug 1, 1997·Seminars in Cell & Developmental Biology·S J Ward, G M Morriss-Kay

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Citations

Jul 1, 2006·The British Journal of Ophthalmology·P GogateC Gilbert
Feb 25, 2003·The British Journal of Ophthalmology·S J HornbyC E Gilbert
Dec 14, 2004·Journal of Medical Genetics·C Y Gregory-EvansK Gregory-Evans
Dec 10, 2009·PLoS Medicine·Parikshit GogatePaul Courtright
Jul 1, 2008·Indian Journal of Community Medicine : Official Publication of Indian Association of Preventive & Social Medicine·Sambuddha GhoshGautam Bhaduri
Jul 25, 2013·European Journal of Human Genetics : EJHG·Adi MoryRuth Gershoni-Baruch
Jan 15, 2014·Human Molecular Genetics·Daniel KelbermanJane C Sowden
Feb 14, 2016·European Journal of Medical Genetics·Julie PlaisanciéNicolas Chassaing
Nov 7, 2012·Progress in Retinal and Eye Research·Cheryl Y Gregory-EvansKevin Gregory-Evans
Oct 4, 2008·Chemico-biological Interactions·Gregg Duester
Apr 7, 2005·American Journal of Medical Genetics. Part a·Nicola K RaggeDavid R Fitzpatrick
Sep 21, 2010·Biochimica Et Biophysica Acta·Patricia A GongalAndrew J Waskiewicz
Jul 19, 2002·Prenatal Diagnosis
Dec 7, 2018·Investigative Ophthalmology & Visual Science·Mingzhe CaoShuyi Chen
Aug 26, 2006·Current Opinion in Ophthalmology·Lan ChangBrian P Brooks
May 26, 2020·Fetal and Pediatric Pathology·Maria D GarciaLilly H Wagner
Jul 28, 2020·Obstetric Medicine·Lauren J GreenCharlotte J Frise
Jan 4, 2019·Human Genetics·Cheryl Y Gregory-EvansKevin Gregory-Evans
Aug 24, 2020·The British Journal of Ophthalmology·Shailja TibrewalUNKNOWN Bodhya Eye Consortium
Oct 16, 2020·Veterinary Ophthalmology·Inês Q Saraiva, Esmeralda Delgado
Oct 4, 2008·Development·Chunqiao Liu, Jeremy Nathans

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