Environmental-sensitive micelles based on poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) diblock copolymer for application in drug delivery

International Journal of Pharmaceutics
Ging-Ho HsiueJia-Ling Yang

Abstract

Anticancer drug doxorubicin (DOX) was physically loaded into the micelles prepared from poly(2-ethyl-2-oxazoline)-b-poly(L-lactide) diblock copolymers (PEOz-PLLA). PEOz-PLLA consists of hydrophilic segment PEOz and hydrophobic segment PLLA showed pH-sensitivity in the aqueous solution. The DOX-loaded micelle exhibited a narrow size distribution with a mean diameter around 170 nm. The micellar structure can preserve hydrophobic drug DOX under the physiological condition (pH 7.4) and selectively release DOX by sensing the intracellular pH change in late endosomes and secondary lysosomes (pH 4-5). At 37 degrees C, the cumulated released rate of DOX from micelles was about 65% at pH 5.0 in the initial 24 h. Additionally, polymeric micelles had low cytotoxicity in human normal fibroblast HFW cells for 72 h by using MTT assay. Moreover, DOX-loaded micelles could slowly and efficiency decrease cell viability of non-small-cell lung carcinoma CL3 cells. Taken together, PEOz-b-PLLA diblock polymeric micelles may act as useful drug carriers for cancer therapy.

References

Aug 1, 1992·American Journal of Respiratory Cell and Molecular Biology·P C YangC W Wu
Jan 1, 1991·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A MartoniF Pannuti
Sep 2, 1999·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·M Jones, J Leroux
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·J E ChungT Okano
Jul 14, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·A MarinN Rapoport
Aug 8, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·D E MeyerA Chilkoti
Jul 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Hyuk Sang YooTae Gwan Park
Nov 11, 2003·Biomacromolecules·Chau-Hui Wang, Ging-Ho Hsiue
Jan 7, 2004·Advanced Drug Delivery Reviews·Cornelus F van Nostrum
Aug 18, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xintao ShuaiJinming Gao
Feb 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Martin HrubýKarel Ulbrich
May 24, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Praneet OpanasopitTeruo Okano
May 25, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chun-Liang LoGing-Ho Hsiue
Sep 27, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Chau-Hui WangGing-Ho Hsiue

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Citations

Feb 24, 2010·Journal of Materials Science. Materials in Medicine·Andrey N KuskovAristidis M Tsatsakis
Nov 17, 2006·Pharmaceutical Research·V P Torchilin
Nov 22, 2007·Photochemistry and Photobiology·Buhong LiBrian C Wilson
May 31, 2008·Nanomedicine·Federica ChielliniEmo Chiellini
Jan 23, 2014·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Lin-Chiang Sherlock HuangMing-Hua Hsu
Mar 8, 2014·Daru : Journal of Faculty of Pharmacy, Tehran University of Medical Sciences·Zahra HamiKambiz Gilani
Jun 24, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiang YiAlexander V Kabanov
Mar 15, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rong LiuZhongwei Gu
Feb 12, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Srinivas GantaMansoor Amiji
Jan 22, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joohee JungShun'ichi Kuroda
Jul 6, 2013·Journal of Biomedical Materials Research. Part a·Yi-Chun ChenGing-Ho Hsiue
Oct 2, 2007·Advanced Drug Delivery Reviews·Nico Adams, Ulrich S Schubert
Feb 7, 2017·Chemical Society Reviews·Nane VanparijsBruno G De Geest
Oct 19, 2011·Macromolecular Bioscience·Mehrdad HamidiKobra Rostamizadeh
Oct 5, 2012·Macromolecular Rapid Communications·Ondrej SedlacekMartin Hruby
Aug 7, 2012·Macromolecular Rapid Communications·Robert LuxenhoferRainer Jordan
Jul 7, 2020·Journal of Microencapsulation·Naile OzturkImran Vural
Mar 1, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Chenguang LiShunai Che
Feb 26, 2021·Drug Development and Industrial Pharmacy·Marzieh KazemiMasoomeh Nazarabi
May 8, 2008·The Journal of Organic Chemistry·Saumen HajraBiswajit Maji
Jun 28, 2018·The Journal of Physical Chemistry. B·Aristeidis PapagiannopoulosJudith Elizabeth Houston
Jan 16, 2022·Advanced Healthcare Materials·Violet V SheffeyOmolola Eniola-Adefeso

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