Environmental superbugs: The case study of Pedobacter spp

Environmental Pollution
Ana Teresa VianaSónia Mendo

Abstract

The environment is one of the main reservoirs of antibiotic resistance genes (ARGs) but multidrug resistant (MDR) environmental isolates are barely characterised. As suggested by the name, Pedobacter species have been predominantly isolated from soils, but are also recovered from water (including drinking water), chilled food, fish, compost, sludge, glaciers and other extreme environments. The susceptibility phenotype of Pedobacter lusitanus NL19 (isolated from a deactivated uranium mine), its closely related species and the genus type strain were investigated. All strains are MDR bacteria, resistant to β-lactams, colistin, aminoglycosides and ciprofloxacin. Therefore, Pedobacter spp. are likely intrinsically resistant to β-lactams (including ertapenem) and to other three classes of antibiotics. 6%-8% of their total protein-encoding genes encode a diverse collection of putative ARGs, including β-lactamases. These enzymes are highly abundant in all the other Pedobacter strains with sequenced genomes, especially class C, class B3 and class A. LUS-1 and PLN-1 were further characterised in E. coli. LUS-1 is a class A β-lactamase and it conferred an increase in the MIC of cefotaxime, albeit very low. PLN-1 is a class B3 β-lactamase ...Continue Reading

Citations

Jul 31, 2019·Environmental Microbiology·Jaime Carrasco, Gail M Preston
Mar 16, 2021·Frontiers in Microbiology·Joakim BjerketorpAnders Broberg
Aug 11, 2020·Marine Pollution Bulletin·Vanessa Costa AndradeAna Júlia Fernandes Cardoso de Oliveira
Feb 7, 2022·Antonie van Leeuwenhoek·Le Tran Tien ChauChang-Jun Cha

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