Environmental toxicants in breast milk of Norwegian mothers and gut bacteria composition and metabolites in their infants at 1 month

Microbiome
Nina IszattMerete Eggesbø

Abstract

Early disruption of the microbial community may influence life-long health. Environmental toxicants can contaminate breast milk and the developing infant gut microbiome is directly exposed. We investigated whether environmental toxicants in breastmilk affect the composition and function of the infant gut microbiome at 1 month. We measured environmental toxicants in breastmilk, fecal short-chain fatty acids (SCFAs), and gut microbial composition from 16S rRNA gene amplicon sequencing using samples from 267 mother-child pairs in the Norwegian Microbiota Cohort (NoMIC). We tested 28 chemical exposures: polychlorinated biphenyls (PCBs), polybrominated flame retardants (PBDEs), per- and polyfluoroalkyl substances (PFASs), and organochlorine pesticides. We assessed chemical exposure and alpha diversity/SCFAs using elastic net regression modeling and generalized linear models, adjusting for confounders, and variation in beta diversity (UniFrac), taxa abundance (ANCOM), and predicted metagenomes (PiCRUSt) in low, medium, and high exposed groups. PBDE-28 and the surfactant perfluorooctanesulfonic acid (PFOS) were associated with less microbiome diversity. Some sub-OTUs of Lactobacillus, an important genus in early life, were lower in ab...Continue Reading

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Aug 28, 2019·Environmental Science and Pollution Research International·Martyna Pajewska-SzmytBogusław Buszewski
Dec 12, 2019·Expert Review of Proteomics·Flaminia BardanzelluAlessandra Coscia
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Methods Mentioned

BETA
amplicon sequencing

Software Mentioned

Qiime2
glmnet
PERMANOVA
STATA
Greengenes
PICRUSt
R programme
Deblur
Quantitative Insights Into Microbial Ecology ( QIIME ) pipeline
ANCOM

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