Environmental toxicants, incidence of degenerative diseases, and therapies from the epigenetic point of view

Archives of Toxicology
Mahshid HodjatMohammad Abdollahi

Abstract

Epigenotoxicology is an emerging field of study that investigates the non-genotoxic epigenetic effects of environmental toxicants resulting in alteration of normal gene expression and disruption of cell function. Recent findings on the role of toxicant-induced epigenetic modifications in the development of degenerative diseases have opened up a promising research direction to explore epigenetic therapy approaches and related prognostic biomarkers. In this review, we presented comprehensive data on epigenetic alterations identified in various diseases, including cancer, autoimmune disorders, pulmonary conditions as well as cardiovascular, gastrointestinal and bone disease. Although data on abnormalities of DNA methylation and their role in the development of diseases are abundant, less is known about the impact of histone modifications and microRNA expressions. Further, we discussed the effects of selected common environmental toxicants on epigenetic modifications and their association with particular abnormalities. A number of different environmental toxicants have been identified for their role in aberrant DNA methylation, histone modifications, and microRNA expression. Such epigenetic effects were shown to be tissue-type spec...Continue Reading

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Citations

Apr 16, 2018·Environmental and Molecular Mutagenesis·Mariolina GullìGiovanna Visioli
Oct 12, 2017·Archives of Toxicology·Soheila Rahmani, Mohammad Abdollahi
Aug 13, 2017·Basic & Clinical Pharmacology & Toxicology·Samira AlinejadOmid Mehrpour
Apr 23, 2020·Frontiers in Bioengineering and Biotechnology·Seyed Zachariah MoradiMohammad Abdollahi
Apr 20, 2018·Environmental Health Perspectives·Michelle M AngrishBrian N Chorley
Sep 12, 2018·Toxics·Todd LeffRuta Jog
Oct 6, 2017·Environmental Research·Kimberly C PaulBeate Ritz
Aug 25, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Mehdi ZobeiriMohammad Abdollahi

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Methods Mentioned

BETA
sumoylation
acetylation
histone acetylation
ubiquitination
MDS
transfection

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