Environmental toxicity, oxidative stress and apoptosis: ménage à trois

Mutation Research
Rodrigo FrancoMihalis I Panayiotidis

Abstract

Apoptosis is an evolutionary conserved homeostatic process involved in distinct physiological processes including organ and tissue morphogenesis, development and senescence. Its deregulation is also known to participate in the etiology of several human diseases including cancer, neurodegenerative and autoimmune disorders. Environmental stressors (cytotoxic agents, pollutants or toxicants) are well known to induce apoptotic cell death and to contribute to a variety of pathological conditions. Oxidative stress seems to be the central element in the regulation of the apoptotic pathways triggered by environmental stressors. In this work, we review the established mechanisms by which oxidative stress and environmental stressors regulate the apoptotic machinery with the aim to underscore the relevance of apoptosis as a component in environmental toxicity and human disease progression.

References

Sep 19, 1997·Experimental Neurology·C A PiantadosiD E Schmechel
Dec 24, 1997·Environmental Health Perspectives·S A GolladayA E Aust
Nov 5, 1998·The New England Journal of Medicine·S L SoignetR P Warrell
Apr 3, 1999·Toxicology and Industrial Health·I VocciaM Fournier
Feb 3, 2000·Proceedings of the National Academy of Sciences of the United States of America·S R ThomH Ischiropoulos
Mar 18, 2000·Leukemia & Lymphoma·Y AkaoY Nakagawa
Apr 28, 2000·Diabetic Medicine : a Journal of the British Diabetic Association·I C West
Jun 3, 2000·Annual Review of Pharmacology and Toxicology·K B Wallace, A A Starkov
Aug 3, 2000·The Journal of Biological Chemistry·C HuangX Shi
Aug 6, 2000·Cell and Tissue Research·M Verheij, H Bartelink
Oct 18, 2000·Toxicology and Applied Pharmacology·K CarlsonM Ehrich
Oct 31, 2000·Critical Reviews in Toxicology·J D Robertson, S Orrenius
Nov 15, 2000·Toxicology and Applied Pharmacology·K J ShinP G Suh
Apr 18, 2001·Journal of Pediatric Hematology/oncology·H F Ding, D E Fisher
May 17, 2001·Reviews on Environmental Health·B D BanerjeeR S Ahmed
Jul 12, 2001·Toxicology and Applied Pharmacology·U Namgung, Z Xia
Nov 20, 2001·Molecular and Cellular Biology·A KruegerS Kirchhoff
Feb 28, 2002·Biochemical and Biophysical Research Communications·Mariko KitoYoshinori Nozawa
Jun 18, 2002·Journal of Cellular and Molecular Medicine·N Shinomiya
Jul 13, 2002·Journal of Cellular Physiology·Luigi RavagnanGuido Kroemer
Sep 3, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Patricia K TithofMarc Peters-Golden
Sep 7, 2002·Antioxidants & Redox Signaling·Bruce J ShenkerIrving M Shapiro
Sep 20, 2002·The Journal of Biological Chemistry·Amit VermaLeonidas C Platanias

❮ Previous
Next ❯

Citations

Aug 27, 2009·Journal of Neural Transmission·Kurt A Jellinger
Jan 5, 2010·Apoptosis : an International Journal on Programmed Cell Death·Tibor Kiss
Mar 2, 2012·Journal of Biological Physics·Enrique Hernández-Lemus
Dec 31, 2011·Biological Trace Element Research·Yan-Hui HanShi-Wen Xu
Mar 30, 2013·Aquatic Toxicology·Sofia PytharopoulouDimitrios L Kalpaxis
Nov 2, 2013·Biosensors & Bioelectronics·Hamid CharkhkarJoseph J Pancrazio
Jan 16, 2013·Journal of Agricultural and Food Chemistry·Chan-Min LiuJian-Mei Sun
May 3, 2011·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Sarah X L HuangTom K Hei
Sep 11, 2009·Biology of Reproduction·S Mazaud-GuittotB Le Magueresse-Battistoni
Apr 27, 2012·Environmental Health Perspectives·Janie F SheltonIsaac N Pessah
Feb 23, 2011·International Journal of Molecular Sciences·Zhen MaoYan-Qiu Zhang
May 22, 2013·TheScientificWorldJournal·Margaret E Sears
Apr 26, 2014·Biological Trace Element Research·Xuezhi WangXiaojun Kong
Sep 16, 2014·Diabetes & Metabolic Syndrome·Fernanda de Carvalho e SilvaThelma L Skare
Aug 19, 2014·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Marwa A AhmedH Waly
Aug 7, 2014·Chemical Engineering Journal·Jason G ParsonsJ L Gardea-Torresdey
Jan 26, 2013·Annual Review of Pathology·Gang LiuDavid W Kamp
Jun 25, 2014·Environmental Toxicology and Pharmacology·Graciela ChiapellaGladis Magnarelli
Feb 9, 2012·Journal of Environmental and Public Health·Margaret E Sears, Stephen J Genuis
Jul 16, 2014·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Shauna M McKelveyRichard A Murphy
Aug 1, 2014·Journal of Environmental Sciences (China)·Nadjet BenchalgoMichel Fournier
Sep 5, 2012·Marine Environmental Research·Konstantinos GrintzalisStefanos Dailianis
May 29, 2012·Journal of Environmental Management·Larissa Fonseca Andrade-VieiraLisete Chamma Davide
Dec 17, 2011·Toxicology and Applied Pharmacology·Chan-Min LiuYun-Zhi Sun
Nov 1, 2015·The Science of the Total Environment·Carlos Eduardo Delfino VieiraClaudia Bueno dos Reis Martinez
Dec 14, 2011·Journal of Hazardous Materials·Daniela Morais LemeMaria Aparecida Marin-Morales
Sep 6, 2011·Ecotoxicology and Environmental Safety·Daniela Morais LemeMaria Aparecida Marin-Morales
Jun 21, 2011·Toxicology·Emna El Golli-Bennour, Hassen Bacha

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Autophagy Networks

Autophagy is a lysosomal pathway that involves degradation of proteins and functions in normal growth and pathological conditions, through a series of complex networks. The catabolic process involves delivery of proteins and organelles to the lysosome. Here is the latest research on autophagy networks.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Mutation Research
Marisa D Pulido, Alan R Parrish
Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
M JurczukJ Moniuszko-Jakoniuk
Clinica Chimica Acta; International Journal of Clinical Chemistry
M Ahamed, M K J Siddiqui
© 2021 Meta ULC. All rights reserved