Environmental Training And Synaptic Functions In Young And Old Brain: A Presynaptic Perspective

Current Medicinal Chemistry
Tommaso BonfiglioAnna Pittaluga

Abstract

Aging is an unavoidable, physiological process that reduces the complexity and the plasticity of the synaptic contacts in central nervous system (CNS), having profound implications for human wellbeing. The term "cognitive reserve" refers to central cellular adaptations that augment the resilience of human brain to damage and aging. The term "Cognitive training" indicates the cultural, social and physical stimulations proposed as add-on therapy for the cure of central neurological diseases. "Cognitive training" reinforces the "cognitive reserve" permitting to counteract brain impairments and rejuvenating synaptic complexity. The research has begun investigating the clinical impact of the "cognitive training" in aged people, but additional work is needed to definitively assess its effectiveness. In particular, there is a need to understand, by a preclinical point of view, whether "cognitive training" promotes compensatory effects or, alternatively, if it elicits genuine recovery of neuronal defects. Although the translation from rodent studies to the clinical situation could be difficult, the results from pre-clinical models are of high clinical relevance, since they should allow a better understanding of the effects of environme...Continue Reading

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Citations

Sep 26, 2019·Current Medicinal Chemistry·Giacinto Bagetta, Damiana Scuteri
May 28, 2020·International Journal of Molecular Sciences·Raffaella BoggiaAnna Pittaluga

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