Environmental xenobiotics may disrupt normal endocrine function by interfering with the binding of physiological ligands to steroid receptors and binding proteins

Environmental Health Perspectives
B J Danzo

Abstract

The disruption of the reproductive system of male and female animals in the wild has been attributed to environmental chemicals (xenobiotics). The effects seen mirror alterations one might anticipate if the steroid hormone-dependent processes that regulate these systems were impaired. To determine whether xenobiotics (present at a concentration of 100 microM) exert their action through steroid-mediated pathways, we examined their ability to inhibit the binding of [3H]physiological ligands (present at a concentration of 7 nM) to the androgen and estrogen receptors, rat androgen-binding protein (ABP), and human sex hormone-binding globulin (hSHBG). The gamma- and delta-isomers of hexachlorocyclohexane, congeners of dichlorodiphenyl-trichloroethane (DDT; p,p'-DDT; p,p'-DDE; o,p'-DDT), dieldrin, atrazine, and pentachlorophenol, caused a statistically significant inhibition of specific binding of [3H]5 alpha-DHT to the androgen receptor that ranged from 100% (p,p'-DDE) to 25% (dieldrin). Methoxychlor, o,p'-DDT1, pentachlorophenol, and nonylphenol significantly reduced [3H]17 beta-estradiol binding to the estrogen receptor by 10, 60, 20, and 75%, respectively. The binding of [3H]5 alpha-DHT to ABP was inhibited 70% by the delta-isome...Continue Reading

References

Aug 15, 1977·European Journal of Biochemistry·W Heyns, P De Moor
Jan 1, 1979·Pharmacology & Therapeutics·J R AllenF S Lin
Jan 1, 1977·Obstetrics and Gynecology·M BibboG L Wied
Sep 12, 1992·BMJ : British Medical Journal·E CarlsenN E Skakkebaek
Oct 1, 1992·International Journal of Andrology·A Giwercman, N E Skakkebaek
May 1, 1991·Environmental Health Perspectives·A M SotoC Sonnenschein
Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·B J DanzoB W Bell
Feb 10, 1989·Cell·M Beato
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·A M NakhlaW Rosner
Oct 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·S A KrupenkoB J Danzo
Jul 1, 1994·Endocrinology·R WhiteM G Parker
Oct 1, 1993·Environmental Health Perspectives·T ColbornA M Soto

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Citations

Dec 19, 2009·Environmental Health Perspectives·Mark P PurdueKatherine A McGlynn
Aug 27, 2013·International Journal of Hygiene and Environmental Health·Carmen FreireSergio Koifman
Dec 9, 2000·Biochemical and Biophysical Research Communications·S KubotaY Seyama
May 30, 2014·Environmental Science and Pollution Research International·Barbora JarošováLudek Bláha
Dec 31, 1997·Environmental Health Perspectives·J D McKinney
Jul 28, 1999·Environmental Health Perspectives·C WalkerJ Vandenbergh
Mar 17, 2001·Environmental Health Perspectives·S M Snedeker
Jun 13, 2002·Environmental Health Perspectives·Edward F OrlandoLouis J Guillette
Mar 14, 2003·Environmental Health Perspectives·M M MumtazC T De Rosa
May 4, 2004·Environmental Health Perspectives·Jennifer E Fox
Jul 9, 2004·Environmental Health Perspectives·Sara I Storrs, Joseph M Kiesecker
Feb 3, 2005·Environmental Health Perspectives·Rajiv BhatiaBrenda Eskenazi
Jun 2, 2006·Reproductive Biology and Endocrinology : RB&E·Reini W BretveldNel Roeleveld
Sep 13, 2006·Environmental Health Perspectives·Aleksander H GiwercmanJens Peter Bonde
Aug 19, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Mary L BiggsStephen M Schwartz
Dec 16, 2010·Environmental Health Perspectives·Rhena DelportChristiaan de Jager
Jul 20, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·James W SimpkinsCharles B Breckenridge
Mar 14, 2001·Journal of Experimental Marine Biology and Ecology·Z BillinghurstM H. Depledge
Oct 18, 2003·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hwa-Young SonMasao Hirose
Apr 18, 2002·Archives of Environmental Health·W KarmausH Kruse
Aug 12, 1999·International Journal of Andrology·S CarreauJ Levallet
Oct 20, 2005·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·Ewa WallinLars Hagmar
Apr 15, 2004·Toxicology and Applied Pharmacology·Géraldine LemaireRoger Rahmani
Dec 9, 2008·SAR and QSAR in Environmental Research·A RoncaglioniE Benfenati
Feb 28, 2001·The Journal of Steroid Biochemistry and Molecular Biology·H Hodgert JuryG L Hammond
Dec 11, 2013·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Ryan MatsudaDavid S Hage
Feb 18, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Gina La SalaMassimo De Felici
Jan 22, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Tessie PauloseJodi A Flaws
Apr 9, 2002·Journal of Toxicology and Environmental Health. Part a·Seung Jun KwackKui Lea Park
Nov 14, 2008·Environmental Science and Pollution Research International·J M Navas, H Segner
May 16, 2006·International Journal of Environmental Research and Public Health·Waneene C Dorsey, Paul B Tchounwou
Jan 23, 2009·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eline P Meulenberg
Mar 7, 2002·Environmental Toxicology and Chemistry·Luz Tavera-MendozaDavid Marcogliese

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