Environmentally induced asthma

Toxicology Letters
M J Utell, R J Looney

Abstract

Asthma is characterized by inflammation, reversible airway obstruction, and increased airway responsiveness to various stimuli. Despite advances in understanding of the pathophysiology and in developing new treatments, asthma prevalence and mortality have been rising over the last decade, after a steady decline in the 1970s. Risk factors for environmentally induced asthma include air pollutants, tobacco smoke, wood smoke, and excessive allergen exposure. In controlled human chamber studies, asthmatics demonstrate increased susceptibility to outdoor pollutants such as sulfur dioxide, nitrogen dioxide, and acidic particles with acute reductions in lung function during and following exposures; responses are enhanced by increased ventilation, for example during exercise, or breathing cold air and/or dry air. The evidence is even stronger that inhaled indoor allergens have a causal relationship to asthma. It is possible that changes in housing conditions have led to increased levels of dust mite and other proteins in homes with consequent increases in the prevalence of sensitization. Avoidance of specific allergens such as house dust mite over months results in a reduction in clinical symptoms and bronchial hyperresponsiveness. The ...Continue Reading

References

Dec 1, 1992·The Journal of Pediatrics·R S CallT A Platts-Mills
Oct 1, 1992·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R SporikT A Platts-Mills
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Citations

Nov 12, 2005·International Archives of Occupational and Environmental Health·Josje H E ArtsRuud A Woutersen
Jul 11, 2012·Environmental Toxicology·Keiki OginoYoshihisa Fujikura
Apr 26, 2001·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·C R KumanaW K Lam

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