Environmentally induced epigenetic transgenerational inheritance of ovarian disease.

PloS One
Eric E NilssonMichael K Skinner

Abstract

The actions of environmental toxicants and relevant mixtures in promoting the epigenetic transgenerational inheritance of ovarian disease was investigated with the use of a fungicide, a pesticide mixture, a plastic mixture, dioxin and a hydrocarbon mixture. After transient exposure of an F0 gestating female rat during embryonic gonadal sex determination, the F1 and F3 generation progeny adult onset ovarian disease was assessed. Transgenerational disease phenotypes observed included an increase in cysts resembling human polycystic ovarian disease (PCO) and a decrease in the ovarian primordial follicle pool size resembling primary ovarian insufficiency (POI). The F3 generation granulosa cells were isolated and found to have a transgenerational effect on the transcriptome and epigenome (differential DNA methylation). Epigenetic biomarkers for environmental exposure and associated gene networks were identified. Epigenetic transgenerational inheritance of ovarian disease states was induced by all the different classes of environmental compounds, suggesting a role of environmental epigenetics in ovarian disease etiology.

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Datasets Mentioned

BETA
GSE
33423

Methods Mentioned

BETA
immunoprecipitation
MeDIP-Chip
Chip
chips
Assay

Software Mentioned

Pathway
Pathway Studio
Partek Genomic Suite
Graph Pad Prism
Pathway Express
Onto
R
Graph Pad
Tools
R Foundation for Statistical Computing

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