Environmentally Self-Adaptative Nanocarriers Suppress Glioma Proliferation and Stemness via Codelivery of shCD163 and Doxorubicin

ACS Applied Materials & Interfaces
Jie LiuYiquan Ke

Abstract

Gliomas-devastating intracranial tumors with a dismal outcome-are in dire need of innovative treatment. Although nanodrugs have been utilized as a target therapy for certain types of solid tumors, their therapeutic effects in gliomas are limited due to the complications of the systemic circulation, blood-brain barrier (BBB), and specific glioma environment. Thus, we aimed to establish a nanoliposome adaptable to different environments by codelivery of shCD163 and doxorubicin (DOX) to treat gliomas. In this study, we first synthesized pH-sensitive DSPE-cRGD-Hz-PEG2000 to form an environmentally self-adaptative nanoliposome (cRGD-DDD Lip) via a thin film method. We used in vitro BBB models, in vitro cell uptake experiments, and in vivo biodistribution assays to confirm the long circulation time and low cell uptake of the cRGD-DDD Lip as a result of the poly(ethylene glycol) (PEG) shell of cRGD-DDD Lip in the neutral pH systemic circulation. Moreover, the cRGD-DDD Lip bypassed the BBB and attached to the intracranial glioma following the removal of the PEG shell and the exposure of cRGD to the weakly acidic tumor microenvironment. We further assembled the shCD163/DOX@cRGD-DDD Lip through cRGD-DDD Lip loading of shCD163 and DOX. In...Continue Reading

References

Dec 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·G J QuigleyA Rich
Jan 1, 1996·Annual Review of Cell and Developmental Biology·E Ruoslahti
May 7, 2003·Chemico-biological Interactions·Hayet Tayeb-Bel HajArlette Garnier-Suillerot
Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks
Apr 9, 2005·Cell Death and Differentiation·G Di MairaM Ruzzene
Aug 2, 2008·The New England Journal of Medicine·Patrick Y Wen, Santosh Kesari
Mar 20, 2010·Molecular Immunology·Hanne Van GorpHans J Nauwynck
Oct 12, 2011·The Journal of Biological Chemistry·Hiroaki IkushimaKohei Miyazono
Mar 21, 2015·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·O van TellingenH E de Vries
May 6, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Todd VanArsdaleRobert T Abraham
Sep 20, 2015·Journal of Molecular Endocrinology·Ying YingShiwei Li
Mar 19, 2016·The Journal of Pharmacy and Pharmacology·Ann-Marie Meredith, Crispin R Dass
Nov 29, 2016·Drug Discovery Today·Maximiliano CagelDiego A Chiappetta
Sep 19, 2017·Chemico-biological Interactions·Keyu He, Meng Tang
May 18, 2018·Current Medicinal Chemistry·Wang LiaoJun Liu
Aug 4, 2018·Neurologic Clinics·Martin J van den Bent, Susan M Chang
Feb 6, 2019·Nanomaterials·Stefania NardecchiaHouria Boulaiz
Apr 3, 2019·The Journal of Gene Medicine·Jiayan WuXuesi Chen
Sep 16, 2019·Behavioural Brain Research·Carolina Vieira CardosoEduardo Fernandes Bondan
Nov 16, 2019·Journal of Controlled Release : Official Journal of the Controlled Release Society·Xiaoyi WangWeiyue Lu
Dec 14, 2019·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel Y ZhangAdam M Sonabend
Jan 31, 2020·Journal of Biomedical Nanotechnology·Yihong HeJiagang Liu
Jul 28, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·A J Vargas LópezG Rodríguez-Boto
Jul 28, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jie ZhangJufang Chi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Related Papers

Upsala Journal of Medical Sciences
Yiwen Jiang, Lene Uhrbom
International Journal of Pharmaceutics
Marcela Tavares LuizMarlus Chorilli
© 2021 Meta ULC. All rights reserved