Enzymatic activity mastered by altering metal coordination spheres.

Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry
Isabel MouraJosé J G Moura

Abstract

Metalloenzymes control enzymatic activity by changing the characteristics of the metal centers where catalysis takes place. The conversion between inactive and active states can be tuned by altering the coordination number of the metal site, and in some cases by an associated conformational change. These processes will be illustrated using heme proteins (cytochrome c nitrite reductase, cytochrome c peroxidase and cytochrome cd1 nitrite reductase), non-heme proteins (superoxide reductase and [NiFe]-hydrogenase), and copper proteins (nitrite and nitrous oxide reductases) as examples. These examples catalyze electron transfer reactions that include atom transfer, abstraction and insertion.

References

Jul 15, 1992·FEMS Microbiology Letters·H ShounJ Sugiyama
Apr 19, 1982·FEBS Letters·S P AlbrachtR K Thauer
Oct 29, 1982·Biochemical and Biophysical Research Communications·J J MouraJ LeGall
Feb 16, 1995·Nature·A VolbedaJ C Fontecilla-Camps
Jul 5, 1996·The Journal of Biological Chemistry·M KobayashiH Shoun
Aug 10, 1999·Nature·O EinsleP M Kroneck
Mar 4, 2000·Nature Structural Biology·K BrownC Cambillau
Dec 29, 2000·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·C AscensoJ J Moura
Feb 24, 2001·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·H LopesJ J Moura
Jan 31, 2002·Journal of the American Chemical Society·Peng ChenEdward I Solomon
Mar 27, 2002·Methods in Enzymology·Frank RusnakJosé J G Moura
Jun 20, 2002·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Michael W W AdamsMichael K Johnson
Oct 3, 2002·The Biochemical Journal·Tuomas HaltiaKristina Djinovic-Carugo
Jun 13, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ole FarverIsrael Pecht
Aug 12, 2003·Nature Structural Biology·Michela G BerteroNatalie C J Strynadka
Dec 18, 2003·Journal of the American Chemical Society·Somdatta GhoshEdward I Solomon
Aug 13, 2004·Angewandte Chemie·Peng ChenEdward I Solomon
Sep 16, 2004·Biochemistry·Sofia R PauletaGraham W Pettigrew
Jan 26, 2005·Biochemical Society Transactions·B BurlatD J Richardson
Apr 2, 2005·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Anne VolbedaJuan C Fontecilla-Camps
Jan 5, 2006·Journal of the American Chemical Society·Serge I GorelskyEdward I Solomon
Jan 18, 2006·Journal of Inorganic Biochemistry·P J GonzálezJ J G Moura
Jan 26, 2006·Journal of Inorganic Biochemistry·Graham W PettigrewSofia R Pauleta
Feb 17, 2006·Current Opinion in Chemical Biology·Carlos D BrondinoJosé J G Moura
Apr 15, 2006·The Journal of Biological Chemistry·Hein J WijmaGerard W Canters

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Citations

Sep 16, 2010·Inorganic Chemistry·Jay StasserDavid P Goldberg
Dec 17, 2009·Journal of the American Chemical Society·Frances NamusweDavid P Goldberg
Jan 1, 2014·Antioxidants·Marcus W BrazierSteven J Collins
Apr 4, 2014·Chemical Reviews·Luisa B Maia, José J G Moura
Apr 28, 2011·Angewandte Chemie·Hua YangHanadi F Sleiman
Mar 7, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Alejandro K Samhan-AriasJosé J G Moura
Sep 27, 2013·Inorganic Chemistry·Nuno M F S A CerqueiraMaria J Ramos
Sep 21, 2017·Journal of Inorganic Biochemistry·Cíntia CarreiraIsabel Moura

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