Enzymatic activity of albumin shown by coelenterazine chemiluminescence

Luminescence : the Journal of Biological and Chemical Luminescence
N VasselAnthony K Campbell

Abstract

Bioluminescence, the emission of light from live organisms, occurs in 18 phyla and is the major communication system in the deep sea. It has appeared independently many times during evolution but its origins remain unknown. Coelenterazine bioluminescence discovered in luminous jellyfish is the most common chemistry causing bioluminescence in the sea, occurring in seven phyla. Sequence similarities between coelenterazine luciferases and photoproteins from different phyla are poor (often < 5%). The aim of this study was to examine albumin that binds organic substances as a coelenterazine luciferase to test the hypothesis that the evolutionary origin of a bioluminescent protein was the result of the formation of a solvent cage containing just a few key amino acids. The results show for the first time that bovine and human albumin catalysed coelenterazine chemiluminescence consistent with a mono-oxygenase, whereas gelatin and haemoglobin, an oxygen carrier, had very weak activity. Insulin also catalysed coelenterazine chemiluminescence and was increased by Zn(2+). Albumin chemiluminescence was heat denaturable, exhibited saturable substrate characteristics and was inhibited by cations that bound these proteins and by drugs that bin...Continue Reading

References

Jul 1, 1989·Journal of Bioluminescence and Chemiluminescence·A K CampbellD A Compston
Jan 14, 1982·Nature·M B Hallett, A K Campbell
Jun 15, 1997·Analytical Biochemistry·K Teranishi, O Shimomura
Mar 1, 1997·Journal of Bioluminescence and Chemiluminescence·C M ThomsonA K Campbell
Aug 31, 2001·Bioorganic & Medicinal Chemistry Letters·I DevillersJ Marchand-Brynaert
Sep 27, 2001·Proceedings of the National Academy of Sciences of the United States of America·S H HaddockB H Robison
Jun 26, 2002·Biological & Pharmaceutical Bulletin·Ulrich Kragh-HansenMasaki Otagiri
Mar 8, 2003·Methods in Enzymology·J Woodland Hastings, Carl Hirschie Johnson
Mar 21, 2003·Medicinal Research Reviews·Gonzalo Colmenarejo
Jun 1, 1962·Journal of Cellular and Comparative Physiology·O SHIMOMURAY SAIGA
Aug 1, 1963·Journal of Cellular Physiology·O SHIMOMURAY SAIGA
Dec 5, 2003·Analytical Biochemistry·Marko KervinenIlmo E Hassinen
Feb 1, 1952·Archives of Biochemistry and Biophysics·Y HANEDA, E N HARVEY
Sep 20, 2005·Journal of Molecular Biology·Jamie GhumanStephen Curry
Oct 27, 2007·Archives of Biochemistry and Biophysics·Anthony K CampbellKenneth T Wann
Feb 26, 2008·Biochimica Et Biophysica Acta·Katsunori Teranishi, Osamu Shimomura
Dec 23, 2008·Biochimica Et Biophysica Acta·Tullio Pozzan, Rüdiger Rudolf
Oct 17, 2009·Biochemical and Biophysical Research Communications·Yuichi ObaSatoshi Inouye
Dec 15, 2010·Annual Review of Marine Science·Steven H D HaddockJames F Case

❮ Previous
Next ❯

Citations

Sep 25, 2012·Luminescence : the Journal of Biological and Chemical Luminescence·Anthony K Campbell
Feb 24, 2018·Science·Satoshi IwanoAtsushi Miyawaki
Nov 28, 2017·Organic & Biomolecular Chemistry·Mingliang YuanMinyong Li
Nov 4, 2020·Organic & Biomolecular Chemistry·Yuki MizuiYuki Hiruta
Dec 12, 2020·Biological Reviews of the Cambridge Philosophical Society·Emily S Lau, Todd H Oakley
Dec 31, 2020·IScience·Manabu Bessho-UeharaSteven H D Haddock
Oct 16, 2020·International Journal of Molecular Sciences·Shusei KanieYasuo Mitani
Feb 28, 2019·Biochemistry·Hsien-Wei YehHui-Wang Ai
Nov 26, 2020·Bioconjugate Chemistry·Ryo NishiharaRyoji Kurita

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Luminescence : the Journal of Biological and Chemical Luminescence
Anthony K Campbell
Proceedings of the National Academy of Sciences of the United States of America
Steven H D HaddockB H Robison
Biochemical and Biophysical Research Communications
Yuichi ObaSatoshi Inouye
© 2022 Meta ULC. All rights reserved