PMID: 22332357Feb 16, 2012Paper

Enzymatic activity of thymidine kinase of herpes simlex virus strain resistant to H-phosphonates of Acv

Bioorganicheskaia khimiia
A V Gus'kovaIu S Skoblov

Abstract

Cloned laboratory mutants of herpes simplex virus type I resistant to acycloguanosine H-phosphonate have been investigated. For all clones were shown that mutations resulted to increasing of sensitivity to acting of sidofovir. Thymidine kinase of mutant viruses partially preserves the ability to phosphorilate thymidine, but loses the ability to phosphorilate BVDU.

References

May 1, 1980·The Journal of Infectious Diseases·E De ClercqD Shugar
Jan 1, 1993·Journal of Medical Virology·G B Elion
Feb 19, 2003·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Florence Morfin, Danielle Thouvenot
Jun 21, 2003·Nucleosides, Nucleotides & Nucleic Acids·Inna L KarpenkoYury S Skoblov
Mar 15, 1965·Biochimica Et Biophysica Acta·R POMALESG H HITCHINGS

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.