Enzymatic debridement for necrotic wounds

Journal of Wound Care
S J MartinE A Kay

Abstract

In a randomised, double-blind, controlled trial, a comparison was made of the relative efficacy of using streptokinase/streptodornase (Varidase) in a hydrogel (KY Jelly) or the hydrogel alone in the debridement of Grade IV pressure sores. Seventeen subjects aged 57-94 years (mean age 81) took part; 21 sores were studied, 11 of which were randomised to the enzyme treatment regime. Both treatments led to eschar removal; fewer days were needed in the hydrogel-only group (mean 8.1 days, sd 1.8) compared to the enzyme/hydrogel group (mean 11.8 days, sd 2.9), but this was not statistically significant. The results suggest that the use of hydrogel alone may be a cost-effective alternative to the use of streptokinase/streptodornase and hydrogel in the treatment of these wounds.

Citations

Apr 6, 2002·Journal of Wound Care·P M RutterI C Locke
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Oct 4, 2007·Journal of the American Geriatrics Society·Barbara M Bates-Jensen, Catherine H MacLean
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Sep 20, 2021·Drug Discovery Today·Jennifer N Hennigan, Michael D Lynch

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