PMID: 18716339Aug 22, 2008Paper

Enzymatic debriding agents: an evaluation of the medical literature

Ostomy/wound Management
Robert G Smith

Abstract

Although debridement is an essential part of wound care, information to guide evidence-based decisions is limited in the literature. Assuming studies to ascertain the effectiveness of pharmaceutically based enzymatic debridement products are more prolific than studies using nonpharmaceutical debridement options, a literature review was conducted to provide an evidence base to justify current wound care practice. Information on collagenase- and papain-urea-based products was reviewed with emphasis on their functional components, mechanisms of action, and patient considerations. The Medline Database, Cochrane Database of Systematic Reviews, InfoPOEMs, Institute for Clinical Systems Improvement, National Guideline Clearinghouse, and Primary Care Clinical Practice Guidelines were searched for documents published between 1967 and 2007 using the following terms: enzymatic debridement, collagenase, papain-urea, papain-urea chlorophyllin copper complex, wounds, and diabetic foot wounds. Sixteen of of 44 relevant citations obtained fit the established criteria for readability, accuracy, reliability and validity of information. Four of the 16 studies included a control treatment, the external validity of 13 studies was limited due to sma...Continue Reading

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