Enzymatic degradation of cross-linked high amylose starch tablets and its effect on in vitro release of sodium diclofenac

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
M RahmouniJ C Leroux

Abstract

The influence of several physicochemical parameters on enzymatic hydrolysis and the in vitro release of sodium diclofenac (SDic) from cross-linked high amylose starch (Contramid) (CLA) tablets was evaluated. These parameters included pH, ionic strength of the medium, enzyme concentration, compression force and incorporation of gel-forming polymers such as hydroxypropyl methylcellulose (HPMC), poly(ethylene oxide) (PEO) and poly(vinyl alcohol) into the tablet. Pure CLA tablets were incubated in phosphate buffer (pH 6.8) containing alpha-amylase and the extent of enzymatic erosion was determined by gravimetry. Release of SDic from CLA tablets, in the presence of alpha-amylase, was measured using a USP type III dissolution apparatus. For low alpha-amylase concentrations (<2250 IU/l), the drug release was mainly diffusion-controlled. At higher alpha-amylase concentrations (>4500 IU/l) both diffusion and erosion contributed to the release of SDic. The hydrolysis kinetics of CLA tablets by alpha-amylase was biphasic. During the first phase (2-4 h), the hydrolysis rate was hyperbolically related to the alpha-amylase concentration but was practically alpha-amylase concentration-independent during the second phase. Enzymatic erosion and...Continue Reading

References

Aug 1, 1988·Journal of Protein Chemistry·E A MacGregor
Jul 30, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·Y DumoulinM A Mateescu
Jun 5, 1988·Biotechnology and Bioengineering·P ColonnaF Lemarié
Apr 20, 1989·Biotechnology and Bioengineering·W SattlerW Steiner
Jun 20, 1991·Biotechnology and Bioengineering·V M LeloupS G Ring

❮ Previous
Next ❯

Citations

Jan 18, 2007·Archives of Pharmacal Research·Fatemeh AtyabiRassoul Dinarvand
Apr 12, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·E PringelsJ P Remon
Nov 2, 2004·Biological & Pharmaceutical Bulletin·Kora Pattabhi Rama Chowdary, Yarraguntla Srinivasa Rao
Feb 5, 2016·Indian Journal of Microbiology·Nimisha R NairK Madhavan Nampoothiri
Nov 6, 2002·Journal of Biomedical Materials Research·Cyril DésévauxChristiane Girard
Nov 3, 2009·International Journal of Pharmaceutics·F O Onofre, Y-J Wang
Feb 24, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A Cristina FreireJoão Sousa
Jan 2, 2007·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Qun WangYumin Du
May 3, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yuan LiWillem Norde
Jul 19, 2002·Biophysical Journal·Abraham R TzafririHanna Parnas
Apr 26, 2016·Drug Development and Industrial Pharmacy·Teresa NabaisGrégoire Leclair
Dec 17, 2009·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nobuhito ShibataRieko Miura
Jun 16, 2006·Macromolecular Bioscience·Maria Laura ColuccioNiccoletta Barbani
Dec 14, 2011·Journal of Biomaterials Science. Polymer Edition·Sunirmal PalPriyadarsi De
Mar 15, 2021·Applied Biochemistry and Biotechnology·Jai Shankar PaulShailesh Kumar Jadhav
Mar 24, 2021·Extremophiles : Life Under Extreme Conditions·Nisha GuptaShailesh Kumar Jadhav
Mar 24, 2021·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Zahari VinarovPatrick Augustijns
Nov 26, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Pritam DasPatrice Bacchin
Jun 4, 2010·Biomacromolecules·Yuan LiWillem Norde
Feb 21, 2019·Biomacromolecules·Jiří TrousilMartin Hrubý
May 10, 2005·Biomacromolecules·M L ColuccioR Mauri
Nov 11, 2003·Biomacromolecules·Helena S AzevedoRui L Reis

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Controlled Release : Official Journal of the Controlled Release Society
V LenaertsRobert H Marchessault
Journal of Biomedical Materials Research
Cyril DésévauxChristiane Girard
Journal of Controlled Release : Official Journal of the Controlled Release Society
Seppo PohjaJarkko Ketolainen
Journal of Controlled Release : Official Journal of the Controlled Release Society
Y DumoulinM A Mateescu
© 2021 Meta ULC. All rights reserved