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Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates

bioRxiv

Nov 17, 2019

Johan AarumDenise Sheer

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Abstract

Most proteins in cell and tissue lysates are soluble. Here, we show that many of these proteins, including several that are implicated in neurodegenerative diseases, are maintained in a soluble and functional state by association with endogenous RNA, as degradation of RNA invariably lea...read more

Mentioned in this Paper

Amyotrophic Lateral Sclerosis
Nerve Degeneration
Nucleic Acids
Oligonucleotides
RNA
Widespread
Brain Tissue
Proteolysis
Nucleic acid binding protein
Structure
63
5
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Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates

bioRxiv

Nov 17, 2019

Johan AarumDenise Sheer

DOI: 10.1101/841577

Abstract

Most proteins in cell and tissue lysates are soluble. Here, we show that many of these proteins, including several that are implicated in neurodegenerative diseases, are maintained in a soluble and functional state by association with endogenous RNA, as degradation of RNA invariably lea...read more

Mentioned in this Paper

Amyotrophic Lateral Sclerosis
Nerve Degeneration
Nucleic Acids
Oligonucleotides
RNA
63
5

Similar Papers Found In These Feeds

Paper Details
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