Enzymatic hydrogelation of small molecules

Accounts of Chemical Research
Zhimou YangBing Xu

Abstract

Enzymes, a class of highly efficient and specific catalysts in Nature, dictate a myriad of reactions that constitute various cascades in biological systems. Self-assembly, a process prevalent in Nature, also plays important roles in biology, from maintaining the integrity of cells to performing cellular functions and inducing abnormalities that cause disease. To explore enzyme-regulated molecular self-assembly in an aqueous medium will help to understand and control those important biological processes. On the other hand, certain small organic molecules self-assemble in water to form molecular nanofibers and result in a hydrogel, which is referred to as a "supramolecular hydrogel" (and the small molecules are referred to as "supramolecular hydrogelators"). Supramolecular hydrogelators share common features, such as amphiphilicity and supramolecular interactions (pi-pi interactions, hydrogen bonding, and charge interactions among the molecules, among others) that result in nanostructures and form the three-dimensional networks as the matrices of hydrogels. In this Account, we discuss the use of enzymes to trigger and control the self-assembly of small molecules for hydrogelation, which takes place in vitro or in vivo, extra- or ...Continue Reading

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Citations

Aug 22, 2012·Journal of Agricultural and Food Chemistry·Yi LiuGregory F Payne
Jul 9, 2010·Langmuir : the ACS Journal of Surfaces and Colloids·Ye ZhangBing Xu
Aug 22, 2012·Langmuir : the ACS Journal of Surfaces and Colloids·Xinming LiBing Xu
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