PMID: 375225Mar 1, 1979Paper

Enzymatic insertion of purine bases into depurinated DNA in vitro

Proceedings of the National Academy of Sciences of the United States of America
Z LivnehJ Sperling

Abstract

An enzymatic activity that inserts purines into depurinated DNA was found in a soluble enzyme extract of Escherichia coli. This activity brings about the insertion of adenine and guanine into the appropriate apurinic sites in double-stranded DNA by using the corresponding deoxyribonucleoside triphosphates as the purine donors. Magnesium ions are required for this activity, it is inhibited by caffeine, and it does not act on depurinated single-stranded DNA. The insertion activity described here may represent a step in a repair mechanism, "base-insertion repair," whereby apurinic sites (which may occur in double-stranded DNA either due to the removal of damaged purines with specific glycosylases or by spontaneous depurination) are directly filled with the correct missing purine base.

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Citations

Apr 1, 1980·Biochemical Pharmacology·W G Verly
Nov 1, 1987·Mutation Research·M Talpaert-Borlé
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·Z LivnehJ Sperling
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T BehmoarasC Helene
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·R M Schaaper, L A Loeb
May 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·A RazinG L Cantoni
Sep 18, 1980·Nature·B Demple, S Linn
May 28, 1981·Nature·T A KunkelL A Loeb
Jan 1, 1981·Journal of Supramolecular Structure and Cellular Biochemistry·E C FriedbergR A Schultz
Jan 1, 1980·Environmental Mutagenesis·P E Hartman
Jan 1, 1982·Journal of Cellular Biochemistry·P C HanawaltM E Zolan
Sep 1, 1989·Molecular and Cellular Biology·Y Matsumoto, D F Bogenhagen

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