Enzymatic synthesis of cinnamic acid derivatives.

Biotechnology Letters
Gia-Sheu LeeYi-Hsu Ju

Abstract

Using Novozym 435 as catalyst, the syntheses of ethyl ferulate (EF) from ferulic acid (4-hydroxy 3-methoxy cinnamic acid) and ethanol, and octyl methoxycinnamate (OMC) from p-methoxycinnamic acid and 2-ethyl hexanol were successfully carried out in this study. A conversion of 87% was obtained within 2 days at 75 degrees C for the synthesis of EF. For the synthesis of OMC at 80 degrees C, 90% conversion can be obtained within 1 day. The use of solvent and high reaction temperature resulted in better conversion for the synthesis of cinnamic acid derivatives. Some cinnamic acid esters could also be obtained with higher conversion and shorter reaction times in comparison to other methods reported in the literature. The enzyme can be reused several times before significant activity loss was observed.

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Citations

May 25, 2013·Applied Biochemistry and Biotechnology·Sonja M JakovetićZorica D Knežević-Jugović
Apr 30, 2011·Journal of Agricultural and Food Chemistry·Ying Zhong, Fereidoon Shahidi
Nov 3, 2009·Chemical & Pharmaceutical Bulletin·Ravindra Abhykumar FursuleDilip Ashok Patil
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Nov 2, 2019·Scientific Reports·Yossef López de Los SantosNicolas Doucet
May 22, 2019·Applied Biochemistry and Biotechnology·Cristian de Oliveira RomeraPedro Henrique Hermes de Araújo
Nov 29, 2020·Angewandte Chemie·Pornkanok PongpamornPimchai Chaiyen
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Jun 4, 2021·Journal of Oleo Science·Piraporn SombutsuwanKornkanok Aryusuk
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Jan 22, 2011·Journal of Agricultural and Food Chemistry·Bilian ChenLifei Zheng
Sep 25, 2017·Journal of Agricultural and Food Chemistry·Mingshun Chen, Shujuan Yu

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