Enzymatic synthesis of ligand-bearing DNAs for metal-mediated base pairing utilising a template-independent polymerase

Chemical Communications : Chem Comm
Teruki KobayashiMitsuhiko Shionoya

Abstract

We have developed a novel method to synthesise artificial ligand-bearing DNAs utilising a template-independent DNA polymerase. Hydroxypyridone ligand-bearing nucleotides () were successively appended to DNA primers by the enzyme. The resulting strands, tailed with nucleotides, formed Cu(II)-mediated metallo-DNA duplexes through the formation of metal-mediated artificial base pairs (H-Cu(II)-H).

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Citations

Jun 25, 2016·International Journal of Molecular Sciences·Yusuke TakezawaMitsuhiko Shionoya
Feb 20, 2017·Current Opinion in Chemical Biology·Soham Mandal, Jens Müller
May 10, 2017·Organic & Biomolecular Chemistry·Pascal RöthlisbergerMarcel Hollenstein
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Jan 14, 2021·Chemical Communications : Chem Comm·Takahiro NakamaMitsuhiko Shionoya
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Mar 2, 2021·Chemical Society Reviews·Luke K McKenzieMarcel Hollenstein
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Dec 12, 2018·Journal of Inorganic Biochemistry·Pascal RöthlisbergerMarcel Hollenstein
May 13, 2020·Journal of the American Chemical Society·Takahiro NakamaMitsuhiko Shionoya
Oct 23, 2020·ACS Chemical Biology·Marie FlammeMarcel Hollenstein
Nov 17, 2019·Journal of the American Chemical Society·Yusuke TakezawaMitsuhiko Shionoya

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