PMID: 8955882Nov 1, 1996Paper

Enzymatic synthesis of oleamide (cis-9, 10-octadecenoamide), an endogenous sleep-inducing lipid, by rat brain microsomes

Biochemistry and Molecular Biology International
T SugiuraK Waku

Abstract

The enzymatic synthesis of a novel sleep-inducing lipid, oleamide (cis-9,10-octadecenoamide), was studied using rat brain subcellular fractions as enzyme sources. We found that oleamide was formed from oleic acid and ammonia on incubation with a brain homogenate. The enzyme activity catalyzing the formation of oleamide from oleic acid and ammonia was highest in the microsomal fraction among the subcellular fractions. Boiled microsomes did not exhibit appreciable enzyme activity. These results strongly suggest that oleamide can be synthesized enzymatically in the brains of stimulated animals.

Citations

Jan 13, 2000·Biochemical and Biophysical Research Communications·K J Ritenour-RodgersG P Mueller
Mar 26, 2004·Prostaglandins, Leukotrienes, and Essential Fatty Acids·A J Richardson
Dec 7, 2000·Chemistry and Physics of Lipids·N UedaD G Deutsch
Apr 29, 2000·Prostaglandins & Other Lipid Mediators·N Ueda, S Yamamoto
May 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Cameron G LaitJames H Tumlinson
Apr 21, 2007·Cardiovascular Drug Reviews·C Robin Hiley, Pui Man Hoi
Nov 7, 2006·Prostaglandins & Other Lipid Mediators·Shalini ChaturvediGregory P Mueller
Jan 7, 2004·British Journal of Pharmacology·James D LeggettD A Kendall

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