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Enzymatically inactive, exchange-inert Co(III)-carboxypeptidase A: role of inner sphere coordination in peptide and ester catalysis

Biochemistry

Aug 8, 1978

Harold E Van Wart, Bert L Vallee

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Abstract

Catalytically inactive, exchange-inert Co(III)-carboxypeptidase A has been prepared by reaction of Co(II)-carboxypeptidase A with the active-site-directed oxidizing agent m-chloroperbenzoic acid. Co(III)-carboxypeptidase A, isolated by affinity gel filtration chromatography, has the sam...read more

Mentioned in this Paper

Hydrogen Peroxide
Amino Acid [EPC]
Complex (molecular entity)
Fluorescence Spectroscopy
Drug Kinetics
Protein Conformation
Sodium Dithionite
Polypeptides
Carboxypeptidase A Activity
Apoenzymes
Paper Details
References
  • References20
  • Citations12
12
  • References20
  • Citations12
12

Enzymatically inactive, exchange-inert Co(III)-carboxypeptidase A: role of inner sphere coordination in peptide and ester catalysis

Biochemistry

Aug 8, 1978

Harold E Van Wart, Bert L Vallee

PMID: 210789

DOI: 10.1021/bi00609a032

Abstract

Catalytically inactive, exchange-inert Co(III)-carboxypeptidase A has been prepared by reaction of Co(II)-carboxypeptidase A with the active-site-directed oxidizing agent m-chloroperbenzoic acid. Co(III)-carboxypeptidase A, isolated by affinity gel filtration chromatography, has the sam...read more

Mentioned in this Paper

Hydrogen Peroxide
Amino Acid [EPC]
Complex (molecular entity)
Fluorescence Spectroscopy
Drug Kinetics

Related Papers

Paper Details
References
  • References20
  • Citations12
12
  • References20
  • Citations12
12

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