Enzymatically synthesised MnO2 nanoparticles for efficient near-infrared photothermal therapy and dual-responsive magnetic resonance imaging.

Nanoscale
Jin LiuYuzhou Wu

Abstract

Manganese dioxide (MnO2) nanoparticles (NPs) are highly attractive for biomedical applications due to their biocompatibility, stimuli-responsive magnetic resonance imaging (MRI) properties and capability to modulate the hypoxic tumour microenvironment (TME). However, conventional MnO2 NPs do not possess photothermal therapy (PTT) functions except for hybrids with other photothermal materials. Herein, we first reveal the extraordinary photothermal conversion efficiency (44%) of enzymatically synthesised MnO2 NPs (Bio-MnO2 NPs), which are distinct from chemically synthesised MnO2 NPs. In addition, the Bio-MnO2 NPs revealed high thermal recycling stability and solubility as well as dual pH- and reduction-responsive MRI enhancement for tumour theragnosis. These NPs were prepared through a facile MnxEFG enzyme-mediated biomineralization process. The MnxEFG complex from Bacillus sp. PL-12 is the only manganese mineralization enzyme that could be heterologously overexpressed in its active form to achieve Bio-MnO2 NPs without a bacterial host. The hexagonal layer symmetry of the Bio-MnO2 NPs is the key feature facilitating the high photothermal conversion efficiency and TME-responsive T1-weighted MRI. Evaluations both in vitro at the c...Continue Reading

References

Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·J E Post
Apr 1, 2005·Proceedings of the National Academy of Sciences of the United States of America·Samuel M WebbBradley M Tebo
Mar 10, 2009·Journal of the American Chemical Society·Yixin ZhaoClemens Burda
May 18, 2010·Environmental Science & Technology·Mengqiang ZhuDonald L Sparks
May 11, 2011·Nano Letters·Colin M HesselBrian A Korgel
Apr 24, 2012·Journal of the American Chemical Society·Alberto NaldoniVladimiro Dal Santo
Nov 28, 2012·Biochemical Society Transactions·Kati GeszvainBradley M Tebo
Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Cristina N ButterfieldBradley M Tebo
Sep 7, 2013·Journal of Hazardous Materials·Qianqian YuTsuyoshi Hirajima
Dec 24, 2013·Ultrasonics Sonochemistry·Balasubramaniam Gnana Sundara RajSambandam Anandan
Oct 24, 2014·Journal of the American Chemical Society·Xianguang DingJiang Jiang
Jul 22, 2015·Nature Communications·Karen JohnsonChris Greenwell
Jan 28, 2017·Metallomics : Integrated Biometal Science·Cristina N Butterfield, Bradley M Tebo
Mar 16, 2017·ACS Applied Materials & Interfaces·Mei ZhangHu-Lin Jiang
Oct 1, 2017·Nature Communications·Christine A RomanoBradley M Tebo
Aug 4, 2018·Advanced Healthcare Materials·Jabran SaleemChunying Chen
Jan 24, 2019·ACS Applied Materials & Interfaces·Li WangShuyun Zhou
Oct 31, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yanhong SunZhenxin Wang
Sep 29, 2020·Advanced Healthcare Materials·Huige ZhouChunying Chen

❮ Previous
Next ❯

Software Mentioned

Genewiz

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.