Enzyme-Activated Generation of Reactive Oxygen Species from Heterocyclic N-Oxides under Aerobic and Anaerobic Conditions and Its Relevance to Hypoxia-Selective Prodrugs

Chemical Research in Toxicology
Xiulong Shen, Kent S Gates

Abstract

Enzymatic one-electron reduction of heterocyclic N-oxides can lead to the intracellular generation of reactive oxygen species via several different chemical pathways. These reactions may be relevant to hypoxia-selective anticancer drugs, antimicrobial agents, and unwanted toxicity of heterocylic nitrogen compounds.

References

Dec 15, 1975·Biochemical and Biophysical Research Communications·R P Mason, J L Holtzman
May 1, 1978·Antimicrobial Agents and Chemotherapy·W SuterF Knüsel
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·D I Edwards, N S Virk
Mar 1, 1991·British Journal of Cancer·K A BiedermannJ M Brown
Jan 1, 1990·Methods in Enzymology·B Halliwell, J M Gutteridge
Jan 1, 1990·Free Radical Research Communications·J H TocherD I Edwards
May 1, 1990·Archives of Biochemistry and Biophysics·M G Steiner, C F Babbs
Jul 1, 1986·International Journal of Radiation Oncology, Biology, Physics·E M ZemanW W Lee
Jan 1, 1972·Journal of Bacteriology·R M Behki, S M Lesley
Feb 12, 1972·The Veterinary Record·T D Hennessey, J R Edwards
Dec 1, 1972·Journal of Medicinal Chemistry·A J LinA C Sartorelli
Dec 1, 1967·Journal of Bacteriology·S M Lesley, R M Behki
Apr 1, 1984·The Biochemical Journal·B Halliwell, J M Gutteridge
Jan 27, 1983·Biochemical and Biophysical Research Communications·S Boiteux, J Laval
Aug 1, 1984·International Journal of Radiation Oncology, Biology, Physics·P WardmanM R Stratford
Sep 1, 1981·Antimicrobial Agents and Chemotherapy·L BeutinB Kowalski
Oct 27, 1995·Journal of Medicinal Chemistry·A MongeE Hamilton
Jun 1, 1995·Free Radical Biology & Medicine·A P Breen, J A Murphy
May 12, 1995·Journal of Medicinal Chemistry·A MongeM González
Jan 1, 1994·International Journal of Radiation Biology·P WardmanM Tracy
Sep 15, 1994·Biochemical Pharmacology·J H Tocher, D I Edwards
Jan 1, 1997·Radiation Oncology Investigations·R E Durand, P L Olive
Nov 17, 1998·Chemical Research in Toxicology·J S DanielsM M Greenberg
Jun 21, 2001·Chemical Research in Toxicology·F P Guengerich
Sep 13, 2001·Bioorganic & Medicinal Chemistry·B GanleyK S Gates
Oct 10, 2001·The Journal of Biological Chemistry·A M Wilstermann, N Osheroff
Nov 14, 2001·Biochemical Pharmacology·Y M DelahoussayeJ M Brown
Feb 19, 2002·Chemical Reviews·Wendy Knapp Pogozelski, Thomas D. Tullius

❮ Previous
Next ❯

Citations

Sep 20, 2019·International Journal of Molecular Sciences·Aušra Nemeikaitė-ČėnienėNarimantas Čėnas
Jul 13, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michael P HayWilliam R Wilson
Nov 25, 2020·International Journal of Molecular Sciences·Aušra Nemeikaitė-ČėnienėNarimantas Čėnas
Mar 4, 2021·International Journal of Molecular Sciences·Eugene Arthur-BaidooStephan Denifl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.