PMID: 488750Jul 1, 1979Paper

Enzyme activities and morphological appearance in functioning and excluded segments of the small intestine after shunt operation for obesity

Gut
N G AspN O Berg

Abstract

Five patients in whom small-intestinal bypass was performed for severe obesity had a second operation 11-19 months later because of insufficient weight loss. Mucosal enzyme activities and histological appearance were investigated in biopsies from different parts of the functioning and excluded small intestine. These were compared with biopsies form corresponding sites obtained at the first operation. In addition to a prominent increase in length, circumference, and mucosal thickness in the functioning shunt, the disaccharidases and two intracellular beta-galactosidases increased in specific activity,, especially in the distal ileal part of the shunt. In the excluded segment of the small intestine different enzymes showed a different response: trehalase increased and alkaline phosphate decreased significantly. Other enzymes that were measured showed a varied pattern. The results indicated that not only the luminal content but also other, presumably hormonal, factors regulated the enzyme activities, and that different regulating factors influenced the various enzymes differently. The marked adaptive increase in mucosal surface of the functioning shunt could be one factor in explaining the weight stabilisation and, in some cases, ...Continue Reading

References

Jan 1, 1978·Scandinavian Journal of Gastroenterology·E Gudmand-HöyerB Andersen
Jul 1, 1976·The American Journal of Digestive Diseases·G M LevineE Yezdimir
Jan 1, 1977·The American Journal of Clinical Nutrition·R E BarryJ Benfield
Jul 1, 1976·The American Journal of Clinical Nutrition·G A BrayJ Rodin
Sep 10, 1976·European Journal of Clinical Investigation·B M IversenJ H Solhaug
Mar 1, 1975·Archives of Surgery·M D TilsonH K Wright
Sep 1, 1975·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·E J Balthazar, S Goldfine
Jun 19, 1976·British Medical Journal·T R PilkingtonS Day
Jan 1, 1973·Digestion·R H Dowling, M H Gleeson
Jun 1, 1973·Annals of Surgery·H W ScottA B Brill
Jun 1, 1972·Analytical Biochemistry·N G Asp, A Dahlqvist
Jul 1, 1970·Metabolism: Clinical and Experimental·J F RehfeldF Quaade
Jan 1, 1968·Analytical Biochemistry·A Dahlqvist
Aug 1, 1969·American Journal of Surgery·J H Payne, L T DeWind

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Citations

Dec 1, 1985·World Journal of Surgery·J B Bristol, R C Williamson
Jan 1, 1986·Journal of the American College of Nutrition·C A FloresO Koldovský
Jan 1, 1988·Scandinavian Journal of Gastroenterology. Supplement·E O Riecken
Jan 1, 1996·Scandinavian Journal of Gastroenterology. Supplement·E Gudmand-Høyer, H Skovbjerg

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