PMID: 9431688Jan 1, 1996Paper

Enzyme histochemistry in fetal human hearts and kidneys during intrauterine development. Qualitative and quantitative results

Acta Universitatis Palackianae Olomucensis Facultatis Medicae
Karla Punkt, V Lichnovský

Abstract

The activities of three enzymes, glycerol-3-phosphate dehydrogenase, succinate dehydrogenase and dipeptidylpeptidase IV, were histochemically demonstrated and cytophotometrically measured in fetal human hearts and kidneys. During the intrauterine development from the 7th to the 19th week 29 fetuses in 6 stages of age were investigated. Positive enzyme reaction was found in the myocardium of left and right ventricle and septum and in the different parts of the nephron. During the investigated period of development the enzyme activities changed in both heart and kidney. At the 16th week the activities of glycerol-3-phosphate dehydrogenase and succinate dehydrogenase showed the maximum in the heart, in contrast to kidney, where at this stage activity minima of succinate dehydrogenase and dipeptidylpeptidase IV were measured. The myocardium of the right ventricle showed higher metabolic activity than the right one, which could reflect the higher load of the right ventricle in the fetal circulation. Within the nephron differences of enzyme activities were observed. The highest enzyme activities were always measured in the proximal tubules, interpreted as sign of high degree of differentiation.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.