Enzyme immunoassay for serum pancreatic lipase in the diagnosis of pancreatic diseases.

Gastroenterologia Japonica
T HayakawaS Kiriyama

Abstract

To evaluate the diagnostic utility of serum immunoreactive lipase (IRL), serum lipase was determined using an enzyme immunoassay and a turbidimetric method along with total serum amylase in 41 healthy controls, 76 patients with pancreatic disease and 60 with nonpancreatic disease. Serum IRL was elevated in 12 of 13 patients with acute pancreatitis, 12 of 44 with chronic pancreatitis and in 12 of 19 with pancreatic cancer. The IRL was low in 9 of the 44 patients with chronic pancreatitis, which coincided with advanced exocrine pancreatic insufficiency. Overall sensitivities in pancreatic diseases were 59% for serum IRL, 38% for turbidimetric lipase and 51% for amylase, specificities in healthy controls and nonpancreatic diseases were 80% for serum IRL, 86% for turbidimetric lipase and 88% for serum amylase. Serum IRL determination is useful for diagnosis in pancreatic diseases when compared with the conventional determination of serum lipase.

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Citations

Sep 1, 2007·Expert Opinion on Medical Diagnostics·Vitor Faca, Samir Hanash
Apr 22, 2017·The Cochrane Database of Systematic Reviews·Gianluca RompianesiKurinchi Selvan Gurusamy
Apr 21, 2012·BMC Medicine·Ioannis PrassasEleftherios P Diamandis
Jun 10, 2011·Molecular & Cellular Proteomics : MCP·Shalini MakawitaEleftherios P Diamandis
Aug 4, 2020·Pediatrics International : Official Journal of the Japan Pediatric Society·Mitsuyoshi SuzukiToshiaki Shimizu
Dec 18, 2013·Journal of Proteome Research·Mindy PorterfieldLance Wells

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