Enzyme immunoassays as screening tools for catalysts and reaction discovery

Chemical Communications : Chem Comm
Christophe Créminon, Frédéric Taran

Abstract

Enzyme immunoassays are incredibly powerful analytical tools for the quantifiable detection of target molecules in complex media. These techniques, which exploit the fantastic specific binding properties of antibodies, are fast, precise, selective and highly sensitive and thus perfectly adapted to high-throughput detection of important analytes. Although immunoassays have been used routinely by biologists for more than 50 years, especially for diagnostic purposes, it is only recently that chemists have used them to address pure chemical problems. In this feature article, we provide an overview of progress in the development of immunoassays and their use in two main fields of organic chemistry: the identification of efficient catalysts in libraries and the discovery of new chemical reactions.

References

Jan 1, 1990·Methods in Enzymology·P PradellesJ Maclouf
Jan 1, 1989·Current Opinion in Immunology·B Nilsson
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D S TawfikZ Eshhar
Aug 1, 1997·Current Opinion in Biotechnology·D B Smithrud, S J Benkovic
Apr 20, 1999·Nature Biotechnology·O HofstetterB S Green
Aug 31, 2000·Annual Review of Biochemistry·D Hilvert
Oct 13, 2000·Science·A SimeonovK D Janda
Feb 19, 2002·Current Opinion in Biotechnology·D Wahler, J L Reymond
Dec 20, 2002·Angewandte Chemie·Frédéric TaranCharles Mioskowski
Mar 12, 2003·Advanced Drug Delivery Reviews·Bernhard H WeiglCatherine R Cabrera
Jun 19, 2003·Journal of the American Chemical Society·Hiroki OguriYoko Nagumo
Aug 16, 2003·Analytical Chemistry·P DuttaM J Sepaniak
Dec 18, 2003·Angewandte Chemie·Masayuki MatsushitaKim D Janda
Mar 17, 2004·Journal of Pharmaceutical and Biomedical Analysis·Hervé VollandChristophe Creminon
Apr 29, 2004·Angewandte Chemie·Andrew TsourkasLee Josephson
Oct 8, 2005·Angewandte Chemie·Paola VicennatiFrédéric Taran
Oct 29, 2005·Drug Discovery Today·Johan PihlDaniel T Chiu
Dec 29, 2005·Chembiochem : a European Journal of Chemical Biology·Mary M Rozenman, David R Liu
Apr 6, 2006·Journal of the American Chemical Society·Thomas C Maier, Gregory C Fu
Aug 2, 2006·Molecular BioSystems·Hana MatsushitaKim D Janda
Feb 1, 2007·Journal of the American Chemical Society·Aaron B BeelerJohn A Porco
Jul 20, 2007·Analytical Chemistry·Shean-Lee LimHiroshi Ueda
Oct 6, 2007·Angewandte Chemie·Duncan L BrowneJoseph P A Harrity
Feb 21, 2008·Journal of the American Chemical Society·Christian MarkertAndreas Pfaltz
Mar 22, 2008·Angewandte Chemie·Antje Teichert, Andreas Pfaltz
May 20, 2009·Journal of the American Chemical Society·Duncan L BrowneJoseph P A Harrity
Jun 16, 2009·Journal of the American Chemical Society·David J GorinDavid R Liu
Aug 31, 1928·The Journal of Experimental Medicine·K Landsteiner, J van der Scheer
Feb 19, 2010·The Journal of Organic Chemistry·Jennifer L TreeceJeffrey Aubé

❮ Previous
Next ❯

Citations

Aug 15, 2015·Organic & Biomolecular Chemistry·Liping ZhuYoshihiro Ito
Apr 28, 2016·The Analyst·Sean Goggins, Christopher G Frost
Apr 7, 2016·Annual Review of Analytical Chemistry·Marc TschofenEva Stöger
Apr 5, 2017·Analytical Chemistry·Emil F HolmquistMogens Johannsen
May 9, 2018·Chemical Society Reviews·Marc Renom-Carrasco, Laurent Lefort
Dec 15, 2017·Current Protocols in Chemical Biology·Robert A Swyka, David B Berkowitz
Dec 24, 2018·Angewandte Chemie·Eric S IsbrandtStephen G Newman
Apr 13, 2021·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Junku TakaoKenji Sueyoshi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.