Enzyme induction following a single dose of amobarbital in dogs

Journal of Pharmacokinetics and Biopharmaceutics
P A ReillyL Endrenyi

Abstract

The elimination of amobarbital in dogs was investigated by injecting various doses of amobarbital into a given animal. At low doses (3 mg/kg) serum levels declined in a first-order fashion. Superficially, at high doses (20 mg/kg) the relationship between serum concentration and time could be quantitatively characterized by simple one-compartment saturable kinetics. Indeed, qualitatively, saturation of the amobarbital-metabolizing enzymes was indicated by a shallower initial slope of the semilogarithmic concentration--time profile at the high than at the low dose. However, in addition, an acute enzyme induction phenomenon was observed which was indicated by a shorter terminal half-life of amobarbital at the high dose than after the low dose and also by a shortening in antipyrine half-life.

References

Nov 1, 1975·Clinical Pharmacology and Therapeutics·T Inaba, W Kalow
Oct 1, 1976·Clinical Pharmacology and Therapeutics·T InabaW Kalow
Dec 1, 1976·Clinical Pharmacology and Therapeutics·L EndrenyiW Kalow
Aug 23, 1974·European Journal of Clinical Pharmacology·S LindgrenF Sjöqvist
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Citations

Jan 1, 1982·Pharmacology & Therapeutics·R H Levy
Jan 1, 1983·Drug Metabolism Reviews·P G Dayton, J E Sanders
Aug 1, 1985·Journal of Pharmacokinetics and Biopharmaceutics·E A Lane, R H Levy

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