Jan 1, 1982

Enzyme induction in Streptomyces hydrogenans. Comparison of the effects of different steroids to increase the activity of 3 alpha, 20 beta-hydroxysteroid dehydrogenase and of 3 beta, 17 beta-hydroxysteroid dehydrogenase

Zeitschrift für allgemeine Mikrobiologie
B Bauer, L Träger

Abstract

After cultivation of Streptomyces hydrogenans in the presence of different steroids the activity of both 3 alpha, 20 beta-hydroxysteroid dehydrogenase and 3 beta, 17 beta-hydroxysteroid dehydrogenase was determined in the cell homogenate of the microorganism. By comparing the efficacy of the steroids to increase enzyme activities, steroids could be divided into 3 groups: a) steroids which stimulated preferentially the activity of 3 alpha, 20 beta-hydroxysteroid dehydrogenase (e. g., corticosterone), b) steroids which stimulated preferentially 3 beta, 17 beta-hydroxysteroid dehydrogenase (estradiol-17 beta), and c) those behaving intermediately (e. g., progesterone, 5 alpha -dihydrotestosterone). Highest 3 beta, 17 beta-hydroxysteroid dehydrogenase activity could be measured 2 h after addition of 5 alpha-dihydrotestosterone to the culture medium. The activity of 3 alpha, 20 beta-hydroxysteroid dehydrogenase, however, increased continuously up to 4 h. 3 alpha, 20 beta-hydroxysteroid dehydrogenase and 3 beta, 17 beta-hydroxysteroid dehydrogenase syntheses seemed to be controlled by steroids in a non-coordinate manner.

  • References3
  • Citations1

Citations

Mentioned in this Paper

Microorganism
Corticosterone Assay
Dihydrotestosterone Assay
Streptomyces exfoliatus
Progesterone, (9 beta,10 alpha)-Isomer
17 beta-Hydroxysteroid Dehydrogenases
Estradiol, (16 alpha,17 beta)-Isomer
Progesterone
Progesterone [EPC]
Catatoxic Steroids

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