Enzyme Inhibitory Properties, Antioxidant Activities, and Phytochemical Profile of Three Medicinal Plants from Turkey

Advances in Pharmacological Sciences
Gokhan ZenginM Fawzi Mahomoodally

Abstract

We aimed to investigate the inhibitory potential of three medicinal plants (Hedysarum varium, Onobrychis hypargyrea, and Vicia truncatula) from Turkey against key enzymes involved in human pathologies, namely, diabetes (α-amylase and α-glucosidase), neurodegenerative disorders (tyrosinase, acetylcholinesterase, and butyrylcholinesterase), and hyperpigmentation (tyrosinase). The antioxidant potential, phenolic and flavonoid content of ethyl acetate, and methanolic and aqueous extracts were investigated using in vitro assays. The total antioxidant capacity (TAC), β-carotene/linoleic acid bleaching activity, 1,1-diphenyl-2-picrylhydrazyl free radical (DPPH(•)), 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS(•+)), cupric ion reducing antioxidant capacity (CUPRAC), ferric reducing antioxidant power (FRAP), and metal chelating activity on ferrous ions were used to evaluate the antioxidant capabilities of the extracts. The half-maximal inhibitory concentrations (IC50) of the extracts on cholinesterase, tyrosinase, and α-amylase were significantly higher than the references, galantamine, kojic acid, and acarbose, respectively. The half-maximal effective concentrations (EC50) of the extracts on TAC, CUPRAC, and FRAP were si...Continue Reading

References

Jun 1, 1995·Journal of Ethnopharmacology·E YeşiladaY Takaishi
Jun 25, 1999·Free Radical Biology & Medicine·R ReC Rice-Evans
Jul 15, 2006·Phytotherapy Research : PTR·Shoukat ParvezHyunsu Bae
Dec 1, 2006·International Journal of Food Sciences and Nutrition·Reşat ApakErol Erçağ
Jul 8, 2009·International Journal of Molecular Sciences·Te-Sheng Chang
May 19, 2010·International Journal of Molecular Sciences·Takafumi Hasegawa
Jul 27, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Marijana Zovko KončićBranka Zorc
Jul 21, 2012·Fitoterapia·Xiao-Wei YangHai-Sheng Chen
Jan 30, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Abdurrahman AktumsekAhmet Duran
Apr 10, 2013·Asian Pacific Journal of Tropical Biomedicine·R Senthil KumarP Perumal
Oct 16, 2013·Journal of Ethnopharmacology·Seyid Ahmet SargınSelami Selvi
Dec 3, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jae Sue ChoiHyun Ah Jung
Jan 24, 2014·BioMed Research International·M I KazeemI A Ogunwande
Mar 13, 2014·Journal of the Chinese Medical Association : JCMA·Tarik Mohammed ChaoucheFouzia Atik-Bekkara
May 6, 2014·Journal of Ethnopharmacology·Sukru HaytaSelami Selvi
Jul 24, 2014·Chinese Journal of Natural Medicines·Mohammad Bagher GholivandSeyed Mohamad Maassoumi
Oct 15, 2014·Asian Pacific Journal of Tropical Medicine·Avonti Basak TukunMomtaz Begum
Mar 31, 2015·Journal of Ethnopharmacology·Muzaffer MükemreUğur Çakılcıoğlu
May 16, 2015·Asian Pacific Journal of Tropical Medicine·Fatma Sezer SenolOsman Ustun
Jul 19, 2015·Journal of Ethnopharmacology·Behlül GülerEmin Uğurlu
Jul 21, 2015·Journal of Ethnopharmacology·Seyid Ahmet Sargin

❮ Previous
Next ❯

Citations

Dec 25, 2019·Journal of Basic and Clinical Physiology and Pharmacology·Basiru Olaitan AjiboyeBabatunji Emmanuel Oyinloye
Feb 13, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Alaa M Abu-Odeh, Wamidh H Talib

❮ Previous
Next ❯

Methods Mentioned

BETA
Assay

Software Mentioned

SPSS

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Abdurrahman AktumsekAhmet Duran
Natural Product Research
Mariem Ben JemiaMohamed Elyes Kchouk
Evidence-based Complementary and Alternative Medicine : ECAM
Armelle D TchamgoueGabriel A Agbor
© 2022 Meta ULC. All rights reserved