Enzyme-labeled antibodies for the light and electron microscopic localization of tissue antigens

PMID: 6046571May 1, 1967

Enzyme-labeled antibodies for the light and electron microscopic localization of tissue antigens

The Journal of Cell Biology

P K Nakane, G B Pierce

Abstract

Enzymes, either acid phosphatase or horseradish peroxidase, were conjugated to antibodies with bifunctional reagents. The conjugates, enzymatically and immunologically active, were employed in the immunohistochemical localization of tissue antigens utilizing the reaction product of the enzymatic reaction as the marker. Tissues reacted with acid phosphatase-labeled antibodies directed against basement membrane were stained for the enzyme with Gomori's method, and those reacted with peroxidase-labeled antibody were stained with Karnovsky's method. The reaction products of the enzymes localized in the basement membrane. Unlike the preparations of the fluorescent antibody technique, enzyme-labeled antibody preparations were permanent, could be observed with an ordinary microscope, and could be examined with the electron microscope. In the latter, specific localization of antibody occurred in the basement membrane and in the endoplasmic reticulum of cells known to synthesize basement membrane antigens. The method is sensitive because of the amplifying effect of the enzymatic activity. The ultrastructural preservation and localization were better with acid phosphatase-labeled antibody than with peroxidase-labeled antibody, but acid p...Continue Reading

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HTRF: a technology tailored for biomarker determination-novel analytical detection system suitable for detection of specific autoimmune antibodies as biomarkers in nanogram level in different body fluids

Dec 1, 2015·The EPMA Journal·Lukas Einhorn, Kurt Krapfenbauer

Looking at neurotransmitters in the microscope

Oct 27, 2009·Progress in Neurobiology·T Hökfelt

Heat-induced antigen retrieval: mechanisms and application to histochemistry

Jan 2, 2007·Progress in Histochemistry and Cytochemistry·Shuji Yamashita

Intercellular communication within the rat anterior pituitary gland: X. Immunohistocytochemistry of S-100 and connexin 43 of folliculo-stellate cells in the rat anterior pituitary gland

Apr 23, 2004·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Nobuyuki ShirasawaTsuyoshi Soji

Intercellular communication within the rat anterior pituitary: XIV electron microscopic and immunohistochemical study on the relationship between the agranular cells and GnRH neurons in the dorsal pars tuberalis of the pituitary gland

Oct 12, 2007·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Nobuyuki ShirasawaTsuyoshi Soji

Rapid methods of detecting the target molecule in immunohistology using a bioluminescence probe

Mar 13, 2012·Luminescence : the Journal of Biological and Chemical Luminescence·Chun WuYasuyuki Sasaguri

Yolk sac tumours revisited. A review of their many faces and names

Oct 20, 2011·Histopathology·Francisco F NogalesAlina Nicolae

Targeting tyrosine kinases in cancer: the converging roles of cytopathology and molecular pathology in the era of genomic medicine

Aug 14, 2012·Cancer Cytopathology·Catherine I DumurCeleste N Powers

Immunoperoxidase staining of Streptococcus mutans

Dec 1, 1974·Archives of Oral Biology·P BertholdC H Berthold

The subcellular localization of lipid in myelin-free axonal preparations

Jul 23, 1984·Brain Research·T J HendersonG H DeVries

The purification of horseradish peroxidase by affinity chromatography on Sepharose--bound concanavalin A1,2

May 7, 1976·Analytical Biochemistry·M G BrattainT G Pretlow

Subepithelial fibrils associated with the basement membrane of human cervical epithelium

Nov 1, 1972·Journal of Ultrastructure Research·R Laguens

Ultrastructural localization of antibody by antigen label with peroxidase

Oct 1, 1968·Experimental Cell Research·S Avrameas, M Bouteille

Comparison of peroxidase and ferritin labelling of cell surface antigens

Mar 1, 1972·Experimental Cell Research·R BrettonS Avrameas

Immunocytochemical localization of prolactin in pars distalis of the salamander Necturus maculosus

Nov 1, 1975·General and Comparative Endocrinology·S A Thompson, J J Trimble

Interchromosomal connections as revealed by an immunoperoxidase technique applying anti-DNA antibody

Dec 1, 1976·Experimental Cell Research·Y KanayamaK Siota

A choroid plexus lesion in lambs with mesangiocapillary glomerulonephritis

Jan 1, 1977·Journal of Comparative Pathology·K T MorganK W Angus

Toxicological studies on a benzofurane derivative. I. A comparative study with phenobarbital on rat liver

Dec 1, 1990·Toxicology and Applied Pharmacology·W ParzefallR Schulte-Hermann

A plaque assay for murine leukemia virus using enzyme-coupled antibodies

Apr 1, 1977·Virology·B A Nexo

Vibration enhancement of slide-mounted immunofluorescence staining

Jun 16, 2004·Journal of Neuroscience Methods·K X Jacobsen, W A Staines

Immunohistochemical and electron microscopic detection of hepatitis B surface and core antigens

Oct 1, 1978·Experimental and Molecular Pathology·G A CabralG R Dreesman

Experimental autologous immune-complex nephritis: an electron microscope and immunohistochemical study

Aug 1, 1969·Experimental and Molecular Pathology·R Laguens, A Segal

Ultrastructural and immunohistochemical studies of primary cultures of aortic medial cells

Apr 1, 1973·Experimental and Molecular Pathology·K Fisher-DzogaR W Wissler

Immunocytochemical localization of S-100 protein in neurons and glia of hamster cerebellum

Jul 4, 1975·Brain Research·K Tabuchi, W M Kirsch

Primate endocrine function after pancreatico-duodenal-splenic allotransplantation

Oct 1, 1987·Journal of Surgical Oncology·D F Du ToitR Gonin

Early postoperative pancreatic endocrine function after segmental and pancreaticoduodenal allotransplantation in nonimmunosuppressed primates

Apr 1, 1987·Journal of Surgical Oncology·D F Du ToitL Du Toit

Immunoperoxidase staining in the recognition of Aspergillus infections

Jul 1, 1981·Histopathology·E N Saeed, R J Hay

Immunological labeling of oral bacteria after demineralization. An ultrastructural study

May 1, 1981·Journal of Periodontal Research·C H Lai, M A Listgarten

A comparison between the effects of SMS 201-995, bromocriptine and a combination of both drugs on hormone release by the cultured pituitary tumour cells of acromegalic patients

Jul 1, 1987·Clinical Endocrinology·S W LambertsE Del Pozo

The sensitivity of growth hormone and prolactin secretion to the somatostatin analogue SMS 201-995 in patients with prolactinomas and acromegaly

Aug 1, 1986·Clinical Endocrinology·S W LambertsE Del Pozo

Expression of a hepatocyte membrane antigen during hepatocarcinogenesis and in the developing liver of the rat

Apr 15, 1988·International Journal of Cancer. Journal International Du Cancer·M MatsumotoT Fukumoto

Fine structural criteria for pituitary thyrotrophs in immature and mature rats

Nov 1, 1982·The Anatomical Record·F YoshimuraT Yashiro

Immunohistochemical localization of concanavalin A and wheat germ lectin receptors in the normal human spermatozoa

Oct 1, 1982·American Journal of Reproductive Immunology : AJRI·J M Scacciati de CerezoA S Cerezo

The effect of ionizing radiation on the primate pancreas: an endocrine and morphologic study

Jan 1, 1987·Journal of Surgical Oncology·D F Du ToitL Du Toit

Endocrine function after immunosuppression of pancreatic allograft by ionizing irradiation in the primate

May 1, 1986·Journal of Surgical Oncology·D F Du ToitL Du Toit

gamma-Glutamyl transpeptidase of rat liver and hepatoma tissues: an enzyme immunoassay and immunostaining studies

Jan 1, 1983·Annals of the New York Academy of Sciences·N TaniguchiK Dempo

The effect of age, pairing, copulation, and 2-Br-alpha-ergocryptine in the male Mongolian gerbil on the prolactin cells in the anterior pituitary identified by immunocytochemical and Herlant's tetrachrome methods

Mar 1, 1984·The Anatomical Record·R Ortman, F Perez

Absence of functional activity of tissue plasminogen activator in patients with severe forms of von Willebrand's disease

Sep 1, 1987·British Journal of Haematology·C JeanneauY Sultan

Immunoperoxidase techniques in dermatopathology

Sep 1, 1983·Clinical and Experimental Dermatology·C A Holden, D M MacDonald

Islet cell function in long-term surviving primates after segmental pancreatic allotransplantation

May 1, 1988·Journal of Surgical Oncology·D F Du ToitS Wolfe-Coote

Endocrine function after hetero- and ortho-topic segmental pancreatic transplantation in primates

Mar 1, 1988·Journal of Surgical Oncology·D F Du ToitH Davids

Effect of cyclosporine and irradiation on experimental pancreatic allografts in the primate

Mar 1, 1988·Journal of Surgical Oncology·D F Du ToitL Du Toit

GABAergic amacrine cells in rat retina: immunocytochemical identification and synaptic connectivity

Mar 20, 1981·The Journal of Comparative Neurology·J E VaughnC E Ribak

Induction by hydrocortisone of glutamine synthetase in mouse primary astrocyte cultures

Jan 1, 1981·Journal of Neurochemistry·B H JuurlinkL Hertz

Detection and localization of immunoreactive alcohol dehydrogenase protein in the rat testis

Feb 1, 1988·Alcoholism, Clinical and Experimental Research·M YamauchiE Mezey

Immunocytochemistry: its evolution and criteria for its application in the study of epon-embedded cells and tissue

Feb 1, 1986·The American Journal of Anatomy·E J GosselinG D Sorenson

Some improvement in tissue preparation and colloidal-gold immunolabeling for electron microscopy

Feb 1, 1986·The American Journal of Anatomy·S HisanoS Daikoku

Study of glial fibrillary acidic protein in a human glioma cell line grown in culture and as a solid tumor

Feb 1, 1983·Journal of Neurochemistry·J W BigbeeL F Eng

Diphenylhydantoin interstitial nephritis. Roles of cellular and humoral immunologic injury

Jun 1, 1978·The Journal of Pediatrics·L R HymanM R Knieser

Visualizing viral protein structures in cells using genetic probes for correlated light and electron microscopy

Jun 13, 2015·Methods : a Companion to Methods in Enzymology·Horng D OuClodagh C O'Shea

Protein-protein conjugation on a lectin matrix

Mar 21, 1977·Biochemical and Biophysical Research Communications·S Pillai, B K Bachhawat

The localisation of bovine sperm hyaluronidase

Aug 11, 1975·Differentiation; Research in Biological Diversity·S F Gould, M H Bernstein

Biosynthesis of basement membrane by parietal yolk sac cells

Jan 1, 1982·Differentiation; Research in Biological Diversity·G B PierceL Lustig

Association of fibronectin-like antigens in chromatin preparations from rat hepatoma cells

Dec 1, 1990·Archives of Biochemistry and Biophysics·K FukudaJ F Chiu

Normal proliferation rate of galactocerebroside positive oligodendrocytes in brain cell cultures of the hypomyelinated mouse mutant jimpy

Sep 26, 1983·Brain Research·L BologaN Herschkowitz

Morphology of the gut associated lymphoid system in health and disease: a review

Jan 1, 1978·Pathology·R Whitehead, J M Skinner

A Dermatopathologist's Guide to Troubleshooting Immunohistochemistry Part 1: Methods and Pitfalls

Jul 21, 2015·The American Journal of Dermatopathology·Amanda F MarschDirk M Elston

Immunization with ACE (Angiotensin Converting Enzyme) develops diabetic changes in the kidney and retina in diabetogenic rats

Jan 8, 2004·Endocrine Journal·Seikoh NishidaKiyoshi Ichihara

Modification of osteoarthritis by pulsed electromagnetic field--a morphological study

Jun 13, 2003·Osteoarthritis and Cartilage·D McK CiomborB Simon

Standardization in immunohistochemistry

Mar 30, 2001·Applied Immunohistochemistry & Molecular Morphology : AIMM·T J O'Leary

Antigen retrieval immunohistochemistry and molecular morphology in the year 2001

Jun 9, 2001·Applied Immunohistochemistry & Molecular Morphology : AIMM·S R ShiC R Taylor

Mouse mammary tumor biology: a short history

Apr 17, 2007·Advances in Cancer Research·Robert D Cardiff, Nicholas Kenney

Immunohistochemical studies of blood group-related antigens in human superficial esophageal carcinomas

Jun 15, 1991·Cancer·K TauchiT Mitomi

Glutathione S-transferases in chemically induced tumors

Jan 1, 1984·Toxicologic Pathology·P KrausJ Schuppler

Brain hexokinase: immunohistochemical localization at the light microscopic level

Sep 1, 1969·Biochemistry·P A Craven, R E Basford

Purification and characterization of the 4-aminobutyrate--2,ketoglutarate transaminase from mouse brain

Jul 17, 1973·Biochemistry·A SchousboeE Roberts

Use of immunohistochemical and morphologic methods for the identification of human growth hormone-producing pituitary adenomas

Sep 1, 1976·Cancer·A C Nieuwenhuyzen KrusemanA Schaberg

Direct immunoperoxidase staining for Regan isoenzyme of alkaline phosphatase in human tumor tissues

Sep 1, 1976·Cancer·H MiyayamaW H Fishman

The significance of intracytoplasmic proteins in Reed-Sternberg cells

Oct 1, 1978·Cancer·S PoppemaM R Halie

Immunofluorescence of epithelial skin tumors. II. Basement membrane

Jun 1, 1970·Cancer·J M De MoragasR E Jordon

Peptidergic neurones

Apr 10, 1980·Nature·T HökfeltM Schultzberg

Glucose induces closure of single potassium channels in isolated rat pancreatic beta-cells

Nov 5, 1984·Nature·F M AshcroftS J Ashcroft

Ultrastructural visualization of cellular carbohydrate components in rabbit lacrimal gland by means of concanavalin A

Jan 1, 1981·Experimental Eye Research·A Ahmed, A Garner

Biochemical markers in the plasma and tumors of patients with gynecologic malignancies

Jul 15, 1981·Cancer·J R van NagellE J Pavlik

Correlations between presence of spontaneous lesions of the pituitary (adenohypophysis) and plasma prolactin concentration in aged Wistar rats

Jul 1, 1992·Veterinary Pathology·J H van NesselrooijM C Bosland

Salivary, serum, and microbial components of human carious dentin

Jul 1, 1972·Journal of Dental Research·M SumitaniM Tsutsui

Streptococcus sanguis: a model in the application in immunochemical analysis for the in situ localization of bacteria in dental plaque

Jan 1, 1976·Journal of Dental Research·B RosanM A Listgarten

Reporter-nanobody fusions (RANbodies) as versatile, small, sensitive immunohistochemical reagents

Feb 15, 2018·Proceedings of the National Academy of Sciences of the United States of America·Masahito Yamagata, Joshua R Sanes

Immunohistochemistry in Investigative and Toxicologic Pathology

Jul 4, 2018·Toxicologic Pathology·Kyathanahalli S JanardhanRonald A Herbert

Clq production and secretion by fibroblasts

Sep 9, 1976·Nature·M S Al-Adnani, J O McGee

Biological properties of a CD4 immunoadhesin

Apr 12, 1990·Nature·R A ByrnD J Capon

Antigenic changes in nuclear chromatin in 1,2-dimethylhydrazine-induced colon carcinogenesis

Mar 15, 1980·Cancer·J F ChiuD Gootnick

Morphological and immunocytochemical study of rat pancreatic beta cell changes induced by cyclizine

Dec 1, 1984·Journal of Applied Toxicology : JAT·N Hanai

Choline fails to prevent liver fibrosis in ethanol-fed baboons but causes toxicity

Jul 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·C S LieberS Sato

Lobular distribution of alcohol dehydrogenase in the rat liver

Mar 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M YamauchiE Mezey

Maintenance of gonadotrophs in pituitary autografts under the kidney capsules of female rats given sex hormones or LRH

Aug 1, 1980·The American Journal of Anatomy·M ShinoE G Rennels

Characterization of glycoconjugates found in granular cell tumors, with special reference to keratan sulfate

Jan 1, 1990·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·T Ehara, T Katsuyama

Comparison of indirect peroxidase and avidin-biotin-peroxidase complex (ABC) immunohistochemical staining procedures for c-fos in rat brain

Mar 13, 2019·Journal of Anatomy·Jae L ButlerByron A Heidenreich

Enzyme-labeled Antigen Method: Development and Application of the Novel Approach for Identifying Plasma Cells Locally Producing Disease-specific Antibodies in Inflammatory Lesions

Mar 24, 2016·Acta Histochemica Et Cytochemica·Yasuyoshi MizutaniYutaka Tsutsumi

Heterogeneity in the myoglobin content of chicken heart Purkinje fibers

Jan 1, 1986·Histochemistry·M KaihoI Ishiyama

Immunocytochemical detection of desmin in fat-storing cells (Ito cells)

Jul 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Y YokoiK Usui

Enzyme immunoassay (EIA)/enzyme-linked immunosorbent assay (ELISA)

Sep 24, 2005·Clinical Chemistry·Rudolf M Lequin

Milestones in Immunohistochemistry and Molecular Morphology

Feb 12, 2020·Applied Immunohistochemistry & Molecular Morphology : AIMM·Clive R Taylor

2D and 3D immunogold localization on (epoxy) ultrathin sections with and without osmium tetroxide

Feb 15, 2020·Microscopy Research and Technique·Jennifer FlechslerAndreas Klingl

Use of immunohistochemistry in diagnosis of breast epithelial lesions

May 2, 2007·Advances in Anatomic Pathology·Rohit Bhargava, David J Dabbs

Relaxin binds to and elicits a response from cells of the human monocytic cell line, THP-1

Nov 1, 1996·The Journal of Biological Chemistry·D A ParsellE N Unemori

Overview of established and emerging immunohistochemical biomarkers and their role in correlative studies in MRI

May 2, 2019·Journal of Magnetic Resonance Imaging : JMRI·Emaan AlviKenneth R Shroyer

Fine structure of clostridia with special reference to the location of antigens and enzymes

Dec 1, 1967·The Journal of Applied Bacteriology·P D WalkerA Baillie

Symposium on bacterial spores: I. Cytology of spore formation and germination

Mar 1, 1970·The Journal of Applied Bacteriology·P D Walker

Experimental xenotransplantation: a personal history

Jan 22, 2003·Xenotransplantation·John S Najarian

Morphological changes of the pituitary gland and adrenal cortex in rats after application of hormonally active substances for the treatment of DMBA-induced mammary tumors

Jan 1, 1971·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·E HagenP A Stöhr

Ultrastructural identification of corticotropes of the fetal rat. In-vivo and in-vitro immunocytochemistry

Jan 1, 1983·Cell and Tissue Research·F J HemmingP M Dubois

Carcinoembryonic antigen in carcinoma of the uterine cervix: antigen distribution in primary and metastatic tumors

Jan 15, 1982·Cancer·J R van NagellD M Goldenberg

Mathematical Modeling of Bioassays

Mar 11, 2018·Biochemistry. Biokhimii︠a︡·D V SotnikovB B Dzantiev

Recent advances in tissue imaging for cancer research

Dec 12, 2019·F1000Research·Oscar MaiquesVictoria Sanz-Moreno

Localization of antigens in thin sections of bacteria by the immuno-peroxidase technique

Apr 1, 1975·Acta Pathologica Et Microbiologica Scandinavica. Section B, Microbiology· Haugen AA Grov

Demonstration of surface IgM in blood lymphocytes using the immunoperoxidase method

Jan 1, 1973·Blut·H Stein, S Drescher

Immunochemical detection of measles virus in BSC-1 cells. Brief report

Jan 1, 1971·Archiv für die gesamte Virusforschung·D B Boyle, J G Atherton

Immunohistochemical and immunoblotting detection of cytokeratin in smooth muscle tumors

Aug 1, 1990·Acta Pathologica Japonica·K TauchiK Watanabe

Immunocytochemical demonstration of lysosomal matrix vesicles in the arterial wall of the rat

Jan 1, 1988·Histochemistry·V Seydewitz, J Staubesand

Dehydroepiandrosterone and its sulfated derivative reduce neuronal death and enhance astrocytic differentiation in brain cell cultures

Jan 1, 1987·Journal of Neuroscience Research·L BologaE Roberts

The effect of electricity on the myoglobin content of the human heart and skeletal muscles

Jan 1, 1984·Zeitschrift für Rechtsmedizin. Journal of legal medicine·W KeilI Ishiyama

Immunohistochemical and ultrastructural study of gap junction proteins connexin26 and 43 in human arachnoid villi and meningeal tumors

Dec 18, 2002·Journal of Neuropathology and Experimental Neurology·Hidetaka ArishimaToshihiko Kubota

Fibromatosis of the thyroid gland region. An electron-microscopic and enzyme-histochemical study (author's transl)

Feb 10, 1978·Virchows Archiv. A, Pathological Anatomy and Histology·B Schwarzlmüller, F Hofstädter

Cathodoluminescence applied to the study of human glomerulonephritis

Aug 1, 1985·Physics in Medicine and Biology·J F Cavellier, J P Berry

Occult neoplastic cells in lymph node sinuses and recurrence/metastasis of stage II/III gastric cancer

Dec 19, 2013·Oncology Letters·Yasutomo SekidoNaoya Nakamura

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