PMID: 375099Feb 28, 1979Paper

Enzyme-linked immunosorbent assay of antigens from Candida albicans circulating in infected mice and rabbits: the role of mannan

Mycopathologia
R C WarrenL O White

Abstract

Various antisera raised either to antigens of Candida albicans or to sub-lethal infections of blastospores (convalescent sera) were tested for their efficacy in diagnosing systemic disease in artifically infected animals. Globulin from convalescent serum, when conjugated with alkaline phosphatase and used in enzyme-linked immunosorbent assays (ELISA), was the only antiserum type which detected circulating Candida-related antigen in the serum of infected animals. Conjugates made from anti-mannan, anti-blastospore or antimycelial globulin did not detect antigen. Mannan did not appear to be related to an antigen produced in sera of experimentally infected mice. The significance of these results in the diagnosis of systemic candidosis is discussed.

References

Mar 1, 1975·Canadian Journal of Microbiology·E G EvansK T Holland
May 7, 1977·British Medical Journal·R C WarrenL O White
Dec 8, 1975·Mycopathologia·D W Mackenzie, C M Philpot
Nov 1, 1976·The Journal of Clinical Investigation·M H Weiner, W J Yount
Jul 1, 1973·CRC Critical Reviews in Clinical Laboratory Sciences·C L TaschdjianP J Kozinn
Nov 1, 1971·Immunochemistry·T H Birkbeck, J Stephen

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Citations

Aug 1, 1986·European Journal of Clinical Microbiology·V Hopwood, D W Warnock
Sep 1, 1985·Diagnostic Microbiology and Infectious Disease·J K Au-YoungE Goldstein
Feb 1, 1993·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·H E JensenH Schønheyder
Jan 1, 1985·Critical Reviews in Microbiology·D PoulainA Vernes
Jun 25, 1985·Journal of Immunological Methods·V HopwoodJ A Carney

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