PMID: 6112060Apr 1, 1981Paper

Enzyme pattern and marker antigens in nodular "regenerative" hyperplasia of the liver

Cancer
S N Thung, M A Gerber

Abstract

Characteristic alterations of marker enzymes and tumor-associated antigens have been detected in the preneoplastic lesions of experimental hepatocarcinogenesis. An identical pattern of enzyme activity (increased gammaglutamyl transferase, loss of glucose-6-phosphatase, and canalicular adenosine triphosphatase) was demonstrated in a case of nodular "regenerative" hyperplasia of liver. The lack of marker antigens (alphafetoprotein, carcinoembryonic antigen, alpha 1-antitrypsin) in the hyperplastic nodules in this patient may be related to the discontinuation of oral contraceptive steroids four years earlier. The phenotypic changes of enzyme activity suggest that nodular "regenerative" hyperplasia of the liver in man is preneoplastic.

References

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Citations

Jan 1, 1987·Cancer Metastasis Reviews·S Hendrich, H C Pitot
Apr 8, 2011·World Journal of Gastroenterology : WJG·Marek HartlebPiotr Milkiewicz
Jun 1, 1994·Pathology, Research and Practice·H W Altmann
Apr 24, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Archita SoodSammy Saab
Jul 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J A Solis-HerruzoG Castellano
Nov 8, 2002·Biochimica Et Biophysica Acta·Karl-Josef Kallen
Apr 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F BulleG Guellaën
Jan 1, 1986·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·G FischerK W Bock
Nov 1, 1983·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J TazawaS W French

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