Enzyme polymorphism in the classification of human malignant lymphoma

Journal of Cancer Research and Clinical Oncology
H J RadzunM R Parwaresch

Abstract

Recent studies on the polymorphism of lysosomal hydrolases have shown that all individual blood cell types in the human being possess their own isoenzyme pattern. In the present study acid phosphatase activity of normal human B-lymphocytes and of four different types of low-grade malignant non-Hodgkin's lymphomas according to the Kiel classification was estimated. In addition, the isoenzyme pattern of AcP was investigated by isoelectric focusing. Chronic lymphocytic leukemia of B-cell type (N = 9) and centroblastic centrocytic follicular lymphoma (N = 10) demonstrated significantly lower values than lymphoplasmacytic/lymphoplasmacytoid lymphomas (N = 28) and plasmacytomas (N = 8). The isoenzyme pattern of normal human B-lymphocytes comprised 12 bands between pH 6.3 and 3.85. This basical pattern was shared by all four lymphoma entities. Only lymphoplasmatic lymphoplasmacytoid lymphoma and plasmacytoma revealed additional bands, which probably account for the higher net enzyme activity in these cases.

References

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Mar 28, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·H J RadzunH Stein

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Citations

Jan 1, 1991·Leukemia & Lymphoma·S M GignacH G Drexler
Jan 1, 1985·Leukemia Research·H G DrexlerJ Minowada
Jan 1, 1985·Leukemia Research·H G DrexlerJ Minowada
Sep 1, 1983·Archives of Environmental Health·B KaulM H Gewirtz
Jun 1, 1989·Annals of the Rheumatic Diseases·T D Spector, G D Campion
Mar 1, 1989·Annals of the Rheumatic Diseases·M L JenkinsonD L Scott
Aug 1, 1991·Annals of the Rheumatic Diseases·E BaggeA Svanborg

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