Enzyme-Responsive Copolymer as a Theranostic Prodrug for Tumor In Vivo Imaging and Efficient Chemotherapy

Journal of Biomedical Nanotechnology
Bing WangKui Luo

Abstract

With the advance in nanomedicine, diagnostic and therapeutic nanoscale prodrugs have been rapidly developed in the field of cancer treatment. In this study, we constructed an enzyme-responsive polymer-paclitaxel (PTX) prodrug with a biocompatible saccharide-containing polymer backbone through the reversible addition-fragmentation chain transfer (RAFT) polymerization. A near-infrared fluorescent molecule (pheophorbide a) and magnetic resonance imaging (MRI) contrast agent (gadolinium-tetraazacyclododecanetetraacetic acid) were further conjugated onto the copolymer backbone to impart the ability of multimode imaging and tracing, forming the final diagnosis and treatment polymeric prodrug. This prodrug was amphiphilic and was able to self-assemble into uniform-size nanoparticles (80.1 nm). With the specific catalysis of enzymes, the anti-cancer drug, PTX, in the nanoparticles could be effectively released to kill cancer cells. The results of near-infrared fluorescence imaging and MRI showed that the diagnostic prodrug was preferentially concentrated at the tumor site compared with the free imaging reagents, suggesting improved and durable tumor imaging effects, which are beneficial for precise cancer diagnosis. The tumor growth in...Continue Reading

Citations

Sep 20, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Haonan LiKui Luo
Sep 9, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haonan LiKui Luo
Jun 3, 2021·International Journal of Molecular Sciences·Ying SunHao Hu

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