PMID: 6988019Jan 1, 1980Paper

Enzyme therapy and immuno-adsorption by an extra-corporeal device

Biomaterials, Medical Devices, and Artificial Organs
H Hydén

Abstract

An extra-corporeal chamber has been constructed and used for diagnosis, enzyme therapy and immuno-adsorption. The chamber is made from polymethyl-acrylate and the dimensions of the chamber are 10 x 18 x 7 cm. It contains 23 plates with a total area of 0.5 m2. In most cases no pump is used. The active substance is bound covalently to the plate surfaces. The time for each hemoperfusion has been 3-6 hr. No infections, decrease of thrombocytes or other side effects have been observed. By immobilized homologous antisera (F (ab')2), three putative tumour-associated antigens were isolated from cases of hypernephroma. Two children and one adult patient with malignant lymphoma were treated with extra-corporeal L-asparaginase, the latter with repeated remissions of metastases. The level of antibodies against Factor VIII was significantly decreased by chamber immunoadsorption in two cases of hemophilia. A number of kidney transplantation cases received extra-corporeal L-asparaginase pre- and post-operatively to counteract rejection. In all around 50 patients have received extra-corporeal treatment without any adverse effects. The use of the extra-corporeal chamber in other diseases is discussed.

References

Jan 1, 1977·Transactions - American Society for Artificial Internal Organs·L T TapiaA L Rubin
Mar 1, 1977·Scandinavian Journal of Haematology·S Lange, H Hydén
Dec 1, 1975·British Journal of Cancer·E LangvadN Kroeigaard
Jul 14, 1973·Clinica Chimica Acta; International Journal of Clinical Chemistry·O J BjerrumB Weeke
Jan 1, 1972·Transactions - American Society for Artificial Internal Organs·D SampsonG P Murphy
Jan 1, 1973·Scandinavian Journal of Immunology. Supplement·N H Axelsen
Jan 1, 1966·Annual Review of Biochemistry·I Silman, E Katchalski
Dec 1, 1970·Journal of Biomedical Materials Research·H H Weetall

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Citations

May 19, 2010·International Journal of Molecular Sciences·Yoshiki OshidaKoray Gençay

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